PMID: 38900Sep 1, 1979

A noninvasive technique for monitoring response to chemotherapy in human acute leukemia

Cancer
L E PoseyE W Hull

Abstract

To see whether urine enzyme activities could be used as an index in evaluating the disease status of leukemia patients, we examined the activities of four enzymes: arylsulfatases A(AS-A) and B(AS-B), alkaline phosphatase (AP), and lactate dehydrogenase (LDH). AP and LDH showed no consistent patterns. The activities of AS-A and AS-B correlated well with the patient's clinical status, increasing during progression of disease and decreasing toward normal activities during responses to therapy, as judged from bone marrow cellularity and differential. Among 23 untreated patients with a histologic diagnosis of acute leukemia we found increased activities of the urine enzymes in these proportions: AS-A in 23 patients (100%), AS-B in 22 (95.7%), AP in 7 (30.4%), and LDH in 10 (43.5%). Five patients in remission from acute leukemia had normal activities for all four enzymes. In one patient in remission for more than one year, a rise in urinary arylsulfatase activity preceded observable bone marrow relapse by 4 months. Unlike that of serum of urine lysozyme and serum copper, the determination of urine arylsulfatase activities appears to be a consistent, useful indicator of response to antileukemic therapy. In contrast to the determinatio...Continue Reading

Citations

Feb 1, 1977·Annals of Internal Medicine·D RudmanD W Nixon
Dec 11, 1975·Cancer·L R MorganW Meeker
Dec 1, 1971·Journal of Clinical Pathology·J R MannJ Stuart
Jan 1, 1969·Scandinavian Journal of Haematology·G Boysen
Mar 1, 1973·The Medical Clinics of North America·P E Perillie, S C Finch
Jan 1, 1973·Scandinavian Journal of Haematology·H S Petersen
Jan 1, 1969·Acta Haematologica·P Smutka, R D Brunning
Nov 1, 1971·British Journal of Haematology·D CatovskyC Griffin
Dec 1, 1957·Clinica Chimica Acta; International Journal of Clinical Chemistry·L M DZIALOSZYNSKI
Sep 1, 1958·American Journal of Clinical Pathology·P G CABAUD, F WROBLEWSKI
May 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·H BAUMB SPENCER

Related Concepts

Urine
Antineoplastic Agents
Acute Leukemia
Enzymes, antithrombotic
Bone Marrow
Lysozyme Test
Alkaline Phosphatase Measurement
LYZ
Alkaline Phosphatase
Lysozyme

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