PMID: 6987958Feb 1, 1980Paper

A nonpancreatic source of the proteolytic-enzyme amidase and bacteriology in experimental acute pancreatitis

Annals of Surgery
W M Keynes

Abstract

In previous studies of human and experimental acute pancreatitis, three main assumptions have been made. First, that the disease is due to activation of pancreatic proteolytic enzymes in the pancreas with resulting "autodigestion" of the gland. Second, that interstitial pancreatitis is a mild form of hemorrhagic pancreatitis into which it may progress, and third, that bacteria play little part, if any, in the initiation of the disease. These assumptions are now questioned. In the present study in dogs, levels of proteolytic enzymes in blood, thoracicduct lymph and peritoneal fluid were measured using benzoylarginine amide. Raised levels of amidase were found in hemorrhagic, but not with interstitial, pancreatitis, and biochemical examination of amidase suggested it was not a pancreatic protease, but with its broad specificity and stability derived from bacteria. Addition of antibiotic to the blind duodenal loop in hemorrhagic pancreatitis reduced the level of blood amidase, but Trasylol given intravenously did not, nor did it inhibit amidase in vitro. In all animals, histological examination was made of the pancreas at time of death. On bacteriology, it is concluded that experimental interstitial pancreatitis results from damag...Continue Reading

References

Mar 1, 1979·Gut·L A DonaldsonM J Brodie
May 1, 1978·Annals of Surgery·J H Ranson, F C Spencer
Aug 14, 1971·Lancet·E EggermontG Tytgat
Jan 1, 1969·American Journal of Surgery·G P Konok, A G Thompson
Jan 1, 1969·Scandinavian Journal of Gastroenterology·H Schmidt, W Creutzfeldt
Feb 1, 1968·Circulation Research·A S NiesK L Melmon
Mar 1, 1966·American Journal of Surgery·A E Shader, J R Paxton
Jan 1, 1967·Annals of Surgery·J E Trapnell, M C Anderson
Apr 18, 1963·The New England Journal of Medicine·H D GULLICK
Feb 16, 1963·JAMA : the Journal of the American Medical Association·T M ROBINSON, J E DUNPHY
Jun 1, 1963·American Journal of Surgery·A P THALM J HOLLENBERG
Jun 1, 1963·American Journal of Surgery·J J BYRNE, T F BOYD
Jan 18, 1964·British Medical Journal·G K MCGOWAN, M R WILLS
Feb 1, 1964·American Journal of Surgery·J J BYRNE, J JOISON
Aug 1, 1964·Annals of Surgery·J M HOWARDL M SINGH

❮ Previous
Next ❯

Citations

May 1, 1982·Digestive Diseases and Sciences·A R BerryT V Taylor
May 1, 1984·The Japanese Journal of Surgery·R TsuchiyaK Motoshima
Aug 1, 1982·The Journal of Surgical Research·T PullosC Zaiss
Feb 1, 1995·American Journal of Surgery·N S RunkelF G Moody
Feb 27, 1988·British Medical Journal·R E Barry
Mar 1, 1989·Gut·M Blackstone
Sep 1, 1987·The Journal of Surgical Research·L W Traverso, S K MacFarlane
Apr 22, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G ManesP Malfertheiner
Apr 1, 1990·Gastroenterology·M Singh, H Simsek
Mar 1, 1985·American Journal of Surgery·H A HeijH Obertop
Feb 27, 1988·British Medical Journal·P Tyrer
Dec 15, 1984·British Medical Journal·B McConkey
Dec 15, 1984·British Medical Journal
Nov 15, 2020·Current Gastroenterology Reports·Nikhil R Thiruvengadam, Michael L Kochman
Nov 17, 1998·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·T ArendtU R Fölsch
Oct 1, 1986·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·D Grant

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.