A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection

AIDS
Elin KindbergLennart Svensson

Abstract

The human FUT2 gene encodes the alpha(1,2)fucosyltransferase that determines secretor status. Homozygous for the nonsense mutation are called non-secretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. In this study we have investigated the importance of the FUT2 fucosyltransferase activity on the progress of HIV-1 infection. Swedish blood donors (n = 276), 15 long-term non-progressors (LTNP) and 19 progressors were genotyped with respect to the nonsense mutation 428G-->A in the FUT2 gene. In addition 265/276 blood donors and 19 progressors with rapid or expected progression rate were Delta32 CCR5 genotyped. Of 276 blood donors 218 (79%) were found to be secretor positive (se+), either homozygous (se+/+) wild type (30%) or heterozygous (se+/-) (49%) and 58 (21%) were homozygous non-secretors (se-/-). Five LTNP (33%) were found to be secretor-positive (se+/+, se+/-) and 10 (67%) se-/-. Of the 19 individuals with normal HIV-1 progression 15 (79 %) were found to be secretor positive and four (21%) were non-secretors. No frequency differences were found in the Delta32 CCR5 allele among the groups studied. Strong association (P < 0.001) was observed between the nonsense mutation 428G-->A...Continue Reading

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Citations

Jun 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Debora Barreto TeresaChristiane Pienna Soares
Jan 9, 2008·The Journal of Infectious Diseases·Elin KindbergLennart Svensson
Jun 24, 2010·Human Molecular Genetics·Dermot P B McGovernUNKNOWN International IBD Genetics Consortium
Jun 3, 2009·Molecular Biology and Evolution·Anna Ferrer-AdmetllaFerran Casals
Jun 1, 2007·Journal of Clinical Microbiology·Elin KindbergLennart Svensson
Dec 25, 2009·Emerging Infectious Diseases·Johan NordgrenLennart Svensson
Sep 25, 2012·World Journal of Gastroenterology : WJG·Ayinuer AhemanFeng Gao
Jan 28, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Abigail W BighamJairam R Lingappa
Nov 20, 2013·Nutrition Reviews·Esther Castanys-MuñozPedro Antonio Prieto
Jan 10, 2016·Biochimica Et Biophysica Acta·Viktoria Dotz, Manfred Wuhrer
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