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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Acta Neuropathologica

Aug 27, 2019

Sven J. van der LeeHenne Holstege

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Abstract

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longe...read more

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Alleles
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Genes
Multiple Sclerosis
Nerve Degeneration
Parkinson Disease
Mass Spectrometry
Lewy Bodies
Matching
73
2
63
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Acta Neuropathologica

Aug 27, 2019

Sven J. van der LeeHenne Holstege

PMID: 31131421

DOI: 10.1007/s00401-019-02026-8

Abstract

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longe...read more

Mentioned in this Paper

Alleles
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Genes
Multiple Sclerosis
73
2
63

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