PMID: 9539074Apr 16, 1998Paper

A normal platelet count at admission in acute meningococcal disease does not exclude a fulminant course

Intensive Care Medicine
M van DeurenJ W van der Meer

Abstract

To determine the value of the platelet count at admission for the assessment of the severity of disease in acute meningococcal infections. Retrospective and prospective, descriptive patient study. University Hospital Intensive Care Unit (ICU). All patients (n = 92) with acute meningococcal disease from 1985 to 1997, who arrived at the ICU within 12 h after hospital admission and had more than one platelet count during the first 12 h. After admission, platelets dropped in 95% of the patients. At admission, 2/41 (5%) of the non-hypotensive patients and 13/51 (25%) of the hypotensive patients had platelets fewer than 100 x 10(9)/l. During the following 12 h, these percentages increased to 15% and 71%, respectively. Fatalities had, at admission, a median platelet count of 111 x 10(9)/l (range, 19-302 x 10(9)/l), whereas the nadir, occurring at median 7.0 h (range, 1.3-12 h), was 31 x 10(9)/l (range, 12-67 x 10(9)/l). Plasma TNF, measured shortly after admission, correlated better with the platelet nadir (r = -0.65, p < 0.0001) than with the platelet count at admission. Similarly, serum lactate correlated better with the platelet nadir. As platelets drop after admission, the use of the platelet count at admission for the assessment ...Continue Reading

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Citations

May 22, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S C de GreeffM van Deuren
Jul 13, 2000·Critical Care Medicine·S VanderschuerenH Bobbaers
Apr 10, 2002·Critical Care Medicine·Serdar AkcaJean Louis Vincent
Aug 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jambunathan KrishnanAlice Ackerman
Jan 11, 2000·Clinical Microbiology Reviews·M van DeurenJ W van der Meer
Apr 3, 2007·The Journal of Infection·Maciej Michał KowalikHanna Trocha
Aug 30, 2005·Advances in Pediatrics·Petter Brandtzaeg, Marcel van Deuren
Dec 26, 2001·Journal of Endotoxin Research·P BrandtzaegP Kierulf
Dec 26, 2015·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Michael SchwameisBernd Jilma

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