PMID: 3772741Aug 1, 1986Paper

A note on appropriate constraints on the initial input response when applying deconvolution

Journal of Pharmacokinetics and Biopharmaceutics
P Veng-Pedersen, W R Gillespie

Abstract

When deconvolution is employed to estimate cumulative input profiles, nonzero initial values may result unless certain constraints are imposed on the function used to approximate the input response c(t). It is shown that the initial value of the response to a nonimpulse input is zero, i.e., c(t0) = 0, where t0 is the input lag time. If, in addition, the initial value of the impulse response is zero, i.e., c delta (0) = 0, then c'(t0) = 0. Therefore, it is appropriate to impose the constraint c(t0) = 0 in general and c'(t0) = 0 when c delta (0) = 0 if c(t) is the response to a nonimpulse input. The use of such constraints is demonstrated in an example where the cumulative in vivo dissolution profile is estimated by deconvolution.

References

Jun 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·D J Cutler

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Citations

Oct 1, 1991·Journal of Pharmaceutical Sciences·P Veng-Pedersen
Feb 1, 1988·Journal of Clinical Pharmacology·P Veng-Pedersen
Jan 1, 1988·Journal of Clinical Pharmacology·P Veng-Pedersen
Aug 1, 1988·Journal of Pharmacokinetics and Biopharmaceutics·P Veng-Pedersen
Aug 1, 1994·Journal of Pharmacokinetics and Biopharmaceutics·L Dedík, M Durisová
Apr 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·D Verotta

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