A novel 1,2,4-triazole-based copper(II) complex: synthesis, characterization, magnetic property and nuclease activity

Journal of Inorganic Biochemistry
Dong-Dong LiShi-Ping Yan

Abstract

A novel binuclear copper(II) complex [Cu(2)L(mu-SO(4))](PF(6))(2) (1) (L=3,5-bis (bis(pyridine-2-ylmethyl)amino)methyl)-4H-1,2,4-triazol-4-amine) has been synthesized and structurally characterized. X-ray structure shows that the two copper(II) atoms are bridged by one bidentate sulfate ion and the 1,2,4-triazole ring of L with Cu1cdots, three dots, centeredCu2 distance of 4.404A. Each copper(II) center has a distorted trigonal-bipyramidal configuration. Variable-temperature magnetic susceptibility studies (2-300K) indicate the existence of weak antiferromagnetic coupling between the copper(II) ions in complex 1. The interaction of complex 1 with calf thymus DNA (CT-DNA) has been studied by UV absorption, fluorescence spectroscopy, circular dichroism spectroscopy, viscosity and cyclic voltammetry. Furthermore, complex 1 was able to promote single and double strand DNA cleavage in both aerobic and anaerobic conditions, the pseudo-Michaelis-Menten kinetic parameters k(cat)=2.58h(-1) and K(m)=1.2x10(-4)M were obtained for 1. The hydrolytic cleavage of DNA by the complex was supported by the evidence from free radical quenching, anaerobic experiment, thiobarbituric acid-reactive substances (TBARS) assay.

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Citations

Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Maja Sumar RistovicMaria Lalia-Kantouri
Mar 12, 2015·Physical Chemistry Chemical Physics : PCCP·Mohammed Amir HusainMohammad Tabish
Feb 9, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Dejan LazićAna Rilak
May 16, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Farooq Ali ShahCorrado Rizzoli
Sep 14, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·SneŽana RadisavljevićAna Rilak Simović
Aug 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Filitsa DimizaGeorge Psomas
Aug 20, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Alketa TarushiDimitris P Kessissoglou
Sep 7, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Snežana RadisavljevićBiljana Petrović
Jun 23, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Angelina PetrovićJovana Bogojeski

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