A novel abrasive water jet machining technique for rapid fabrication of three-dimensional microfluidic components.

Biomicrofluidics
Ehsan AzarsaMarcello Papini

Abstract

Microfluidic lab-on-a-chip devices are usually fabricated using replica molding, with poly(dimethylsiloxane) (PDMS) casting on a mold. Most common techniques used to fabricate microfluidic molds, such as photolithography and soft lithography, require costly facilities such as a cleanroom, and complicated steps, especially for the fabrication of three-dimensional (3D) features. For example, an often-desired 3D microchannel feature consists of intersecting channels with depth variations. This type of 3D flow focusing geometry has applications in flow cytometry and droplet generation. Various manufacturing techniques have recently been developed for the rapid fabrication of such 3D microfluidic features. In this paper, we describe a new method of mold fabrication that utilizes water jet cutting technology to fabricate free-standing structures on mild steel sheets to make a mold for PDMS casting. As a proof-of-concept, we use this fabrication technique to make a PDMS chip that has a 3D flow focusing junction, an inlet for the sample fluid, two inlets for the sheath fluid, and an outlet. The flow focusing junction is patterned into the PDMS slab with an abrupt, nearly stepwise change to the depth of the microchannel junction. We use...Continue Reading

References

Jan 14, 2000·Electrophoresis·J C McDonaldG M Whitesides
Jul 18, 2002·Accounts of Chemical Research·J Cooper McDonald, George M Whitesides
Jan 31, 2008·Lab on a Chip·Shia-Yen TehAbraham P Lee
Oct 31, 2008·Talanta·Holger Becker, Laurie E Locascio
Dec 22, 2009·Molecular BioSystems·Yolanda Schaerli, Florian Hollfelder
Dec 30, 2009·Electrophoresis·Jinwen ZhouNicolas Hans Voelcker
Apr 13, 2011·Biomedical Microdevices·Lu PengXing-zhong Zhao
Jun 21, 2011·International Journal of Molecular Sciences·Chia-Yen LeeLung-Ming Fu
Mar 2, 2013·Lab on a Chip·Richard NovakRichard A Mathies
Aug 24, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Jong-Min LimRohit Karnik
Nov 28, 2013·Lab on a Chip·Germán CominaDaniel Filippini
Apr 24, 2015·Lab on a Chip·David J GuckenbergerEdmond W K Young
Dec 17, 2015·Journal of Biomechanics·Vera FaustinoGraça Minas
Mar 31, 2016·Electrophoresis·Eric T da CostaCarlos D Garcia
Apr 22, 2016·Lab on a Chip·Nirveek BhattacharjeeAlbert Folch
Oct 19, 2016·Lab on a Chip·Gangadhar EluruSai Siva Gorthi
Dec 10, 2016·Lab on a Chip·Tung-Yi LinPeter B Lillehoj
Jan 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ayaka KamadaChristofer Lendel
Mar 11, 2017·Analytical Chemistry·Niall P MacdonaldMichael C Breadmore
May 16, 2017·Biomicrofluidics·Vaskar GnyawaliScott S H Tsai
Jan 11, 2019·Scientific Reports·Aldenor G SantosJailson B de Andrade
Feb 9, 2019·Scientific Reports·Vaskar GnyawaliMichael C Kolios
Mar 20, 2019·Scientific Reports·Eric M StrohmMichael C Kolios
Jun 22, 2019·Journal of Colloid and Interface Science·Morteza JeyhaniScott S H Tsai
Jan 28, 2020·Small·Morteza JeyhaniScott S H Tsai

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