A novel adjuvant for use with a blood-stage malaria vaccine

Vaccine
J Brian de Souza, J H Playfair

Abstract

An effective vaccine delivery system has been developed for vaccination against a blood-stage malaria infection in mice. Subcutaneous vaccination with a semi-purified asexual blood-stage malaria antigen combined with an adjuvant formulation containing squalane, Tween 80 and pluronic L121 (AF) protected mice infected with a lethal P. yoelii infection against death and greatly reduced the severity and duration of parasitaemia. The adjuvant and the route of immunization are both clinically acceptable, thereby making this an attractive delivery system for a human malaria vaccine. Protective immunity appeared to be associated with an enhancement of both Th1 and Th2 subset cytokines.

References

Jan 1, 1979·Parasite Immunology·J H Playfair, J B De Souza
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S RaychaudhuriN Hanna

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Citations

Sep 1, 1996·FEMS Immunology and Medical Microbiology·A W Cornelissen, T P Schetters
Nov 18, 1997·International Journal for Parasitology·W Trager, J B Jensen
Apr 9, 1999·Vaccine·M GürselG Alaeddinoglu
Nov 6, 2013·Parasite Immunology·J B de Souza
May 23, 1998·Annual Review of Immunology·M F GoodL H Miller
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kaiissar MannoorToru Abo
May 1, 1997·Infection and Immunity·J B De SouzaJ H Playfair

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