A novel adjuvant, mixture of alum and the beta-adrenergic receptor antagonist propranolol, elicits both humoral and cellular immune responses for heat-killed Salmonella typhimurium vaccine

Vaccine
Ebrahim MazloomiShahram Shahabi

Abstract

To determine the efficacy of the mixture of propranolol (PRP), a beta-adrenergic receptor antagonist, and alum, as a new adjuvant, in the induction of humoral and cellular immunity in response to heat-killed Salmonella typhimurium (S. typhimurium) (HKST) as a model vaccine. BALB/c mice were divided into five groups. Mice in the experimental groups received either the HKST vaccine alone or in combination with the adjuvant alum, PRP or the alum-PRP mixture. Mice in the negative control group received phosphate-buffered saline. All mice were immunized two times on days 0 and 14. Two weeks after the last immunization, immune responses to S. typhimurium were assessed. Administration of the alum-PRP mixture as an adjuvant increased the ability of the HKST vaccine to enhance lymphocyte proliferation, shifted the immune response towards a T-helper (Th) 1 pattern and increased S. typhimurium specific IgG, IgG2a and IgG1. This resulted in improved protective immunity against S. typhimurium. Administration of the alum-PRP mixture as an adjuvant in combination with the HKST vaccine, can enhance both humoral and cellular immunity and shift the immune responses to a Th1 pattern.

References

Dec 1, 1965·British Journal of Pharmacology and Chemotherapy·J W BlackR G Shanks
Sep 18, 1997·The Journal of Clinical Investigation·P Panina-BordignonF Sinigaglia
May 28, 2004·Nature Immunology·Lawrence Steinman
Oct 14, 2004·Immunology and Cell Biology·Erik B Lindblad
Apr 28, 2005·Current Drug Targets. Inflammation and Allergy·Brigita Sitkauskiene, Raimundas Sakalauskas
Nov 29, 2005·Nature Immunology·Qizhi TangJeffrey A Bluestone
Dec 15, 2005·Journal of Dermatological Science·Takeshi NakaharaMasutaka Furue
Nov 21, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lorraine B Ware
Mar 1, 2008·Cellular Immunology·Denise L BellingerDianne Lorton
Jun 17, 2008·International Journal of Pharmaceutics·Yvonne PerrieVincent W Bramwell
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jagadeesh BayryDavid F Tough
Jul 25, 2008·European Journal of Immunology·Ennio De GregorioRino Rappuoli
Aug 7, 2008·Human Vaccines·Aldo Tagliabue, Rino Rappuoli
Aug 16, 2008·Journal of Pharmaceutical Sciences·Jennifer H Wilson-WelderBalaji Narasimhan
Dec 9, 2008·Trends in Immunology·Steven G ReedMartin Friede
Mar 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kristie M GrebeJonathan W Yewdell
Aug 27, 2009·International Immunopharmacology·Agheel Tabar Molla HassanSeyed Mahmoud Hashemi
Jan 13, 2010·Vaccine·Ali M HarandiUNKNOWN Working Group convened by EUROPRISE

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Citations

Dec 3, 2014·International Immunopharmacology·María del R García-MissJosé L Góngora-Alfaro
Apr 5, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ebrahim MazloomiShahram Shahabi
Mar 3, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark J BucsekElizabeth A Repasky
May 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Somayeh AshrafiMehdi Mahdavi
Sep 27, 2018·Experimental Parasitology·Samad MinaeiHabib Mohammadzadeh Hajipirloo

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