A novel albumin wrapped nanosuspension of meloxicam to improve inflammation-targeting effects

International Journal of Nanomedicine
Qi LiWeisan Pan

Abstract

The objective of this study was to develop a more bio-available and safe nanosuspension of meloxicam (MX), which could dramatically improve inflammation targeting. MX-loaded bovine serum albumin (BSA) nanosuspensions were prepared using acid-base neutralization in aqueous solution and the prepared nanosuspensions were characterized. The results obtained showed that the prepared nanosuspensions had a narrow size distribution with a mean particle size of 78.67±0.22 nm, a polydispersity index of 0.133±0.01, and a zeta potential of -11.87±0.91 mV. The prepared MX nanosuspensions were spherically wrapped by BSA with a smooth surface as shown by transmission electron microscopy. Stability studies showed that the nanosuspensions were physically stable at 4°C with a shelf life of at least 6 months. In the in vitro dissolution test, the MX-loaded BSA nanosuspension (MX-BSA-NS) exhibited sustained release. In addition, an in vivo pharmacokinetic study in rats following intravenous injection showed that the half-life (t1/2), mean residence time (MRT), and area under the concentration-time curve (AUC0-∞) of MX-BSA-NS was increased by 169.83%, 150.13%, and 148.80%, respectively, in comparison with MX conventional solution (MX solution). Fur...Continue Reading

Citations

Dec 19, 2019·Recent Patents on Drug Delivery & Formulation·Deepika TakMunish Ahuja
Jun 18, 2019·Recent Patents on Drug Delivery & Formulation·Surya GoelVijay Agarwal
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dongrui LiangAiping Lu
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Hashanthi K Abeyratne-PereraPreethi L Chandran

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
X-ray

Software Mentioned

SPSS
DAS

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