A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2

Tissue Antigens
A Arnaiz-VillenaJ Moscoso

Abstract

The non-classical human leucocyte antigen (HLA) class I locus, HLA-G, shows a low protein polymorphism and a more varied DNA (eight proteins and 28 alleles). HLA-G DNA polymorphism accounts mainly for changes at third codon bases of the protein coding exons; this does not imply amino acid change in most cases. This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G.

References

Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P ParhamP D Ennis
Sep 9, 1999·Journal of Reproductive Immunology·A Arnaiz-VillenaJ Martinez-Laso
Mar 25, 2005·Tissue Antigens·S G E MarshJ Trowsdale
Dec 13, 2006·Transplant Immunology·J MoscosoA Arnaiz-Villena

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Citations

Aug 5, 2009·Human Immunology·Margit Hørup Larsen, Thomas Vauvert F Hviid
May 24, 2008·Tissue Antigens·Steven G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Apr 2, 2010·Tissue Antigens·S G E MarshJ Trowsdale
Oct 22, 2008·Thérapie·Inès Zidi, Aghleb Bartegi

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