PMID: 11319744Apr 25, 2001Paper

A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization

Journal of Biomedical Materials Research
A M AmbrosioC T Laurencin

Abstract

Traditional materials for bone repair or replacements such as autografts and allografts have a limited supply and other complications. Thus, alternative materials need to be explored. Three-dimensional, porous composites prepared from bioresorbable polymers and hydroxyapatite or other calcium phosphate ceramics are promising materials for the repair or replacement of diseased or damaged bone. However, in many cases the ceramic component of these composites is crystalline in nature, while bone apatite is made of a poorly crystalline, carbonated phosphate system. In this study, we synthesized a noncrystalline, carbonated calcium phosphate ceramic by carrying out the reaction within bioresorbable PLAGA microspheres using a modified emulsion/solvent evaporation technique, making each individual microsphere a composite. Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications.

References

May 1, 1992·Calcified Tissue International·A BigiJ S Shah
Oct 23, 1965·Nature·E D EanesA S Posner
Sep 1, 1983·Journal of Biomedical Materials Research·C P KleinA van den Hooff
Jul 1, 1995·Journal of Biomedical Materials Research·K S TenHuisenP W Brown
Jan 1, 1993·Journal of Biomedical Materials Research·L E FreedR Langer
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·J E DevinC T Laurencin
Dec 17, 1998·Journal of Biomedical Materials Research·D KnaackD D Lee
May 13, 1999·Journal of Biomedical Materials Research·R Zhang, P X Ma
Nov 26, 1999·Journal of Biomedical Materials Research·L Keller, W A Dollase
Jul 6, 2000·Journal of Biomedical Materials Research·C Durucan, P W Brown
Jul 25, 2000·Journal of Biomedical Materials Research·E A De MaeyerC W Vercruysse
Nov 10, 2001·Annual Review of Biomedical Engineering·C T LaurencinJ A Cooper

❮ Previous
Next ❯

Citations

Apr 2, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Wen-Chi TsaiHwa-Chang Liu
Jan 31, 2004·Biomaterials·Kai ZhangLorraine F Francis
May 26, 2005·Biomaterials·Youngmee JungSoo Hyun Kim
Sep 17, 2013·Ultrasonics Sonochemistry·Kun HeYu-Peng Lu
Aug 29, 2013·BioMed Research International·Marcello PiliaMark Appleford
Jul 12, 2011·Chemistry Central Journal·Jie ZhaoHai Zhang
Apr 15, 2010·Tissue Engineering. Part a·Hockin H K XuLaurence C Chow
Mar 25, 2008·Dental Materials : Official Publication of the Academy of Dental Materials·Hockin H K XuCarl G Simon
May 5, 2007·Advanced Drug Delivery Reviews·W J E M HabrakenJ A Jansen
Feb 19, 2010·Journal of Biomedical Materials Research. Part a·Michael D Weir, Hockin H K Xu
Aug 24, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ehsan JabbarzadehCato T Laurencin
Jan 7, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marwa Tallawi
Apr 6, 2011·Journal of Biomedical Materials Research. Part a·Francesco Baino, Chiara Vitale-Brovarone
Dec 5, 2009·Clinical Oral Implants Research·Timothy DouglasPatrick H Warnke
Jun 17, 2015·Journal of Tissue Engineering and Regenerative Medicine·Mamoni DashPeter Dubruel
Aug 17, 2014·Tissue Engineering. Part C, Methods·Kathleen HoffmanWojtek Tutak
Apr 4, 2017·International Journal of Biological Macromolecules·Li RuixinLi Hui
Oct 11, 2008·Tissue Engineering. Part B, Reviews·Timothy M O'Shea, Xigeng Miao
Jun 23, 2010·Journal of Biomaterials Science. Polymer Edition·Z Seden AkdemirSabriye Karadenizli
Jul 11, 2006·Journal of Biomedical Materials Research. Part a·Yanbo GaoWeiqi Yan
Oct 6, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Avinash BajiT S Srivatsan
Apr 28, 2007·Journal of Biomedical Materials Research. Part a·J RussiasA P Tomsia
Jul 10, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Oliver D SchneiderWendelin J Stark
Jun 21, 2005·Journal of Materials Science. Materials in Medicine·Y E GreishC T Laurencin
Mar 11, 2010·Journal of Materials Science. Materials in Medicine·C MakarovE Y Gutmanas
Jun 3, 2006·Clinical Orthopaedics and Related Research·Cato T LaurencinJames A Cooper
Mar 6, 2007·Journal of Materials Science. Materials in Medicine·Wei JieLi Yubao
Dec 20, 2005·Expert Review of Medical Devices·Cato LaurencinSaadiq F El-Amin
Mar 1, 2007·Faraday Discussions·Nora H de LeeuwJeremy A L Rabone
Mar 8, 2013·Journal of Materials Science. Materials in Medicine·Sergey V Dorozhkin
Jan 31, 2017·Journal of Functional Biomaterials·Diane R BienekDrago Skrtic
Jul 16, 2014·PloS One·Emily K CushnieCato T Laurencin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.