PMID: 8582330Nov 1, 1995Paper

A novel analog of TRH, YM14673, causes a decrease in brain TRH receptors in vitro

Endocrine Research
T MondenM Mori

Abstract

Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined. We tested effects of YM14673, a novel analog of TRH, on TRH receptors in rat brains in vitro. No significant binding of [3H]YM14673 to brain plasma membranes occurred. In contrast, preincubation of membranes with YM14673 caused dose-dependent decreases in TRH binding. This was not due to competition for TRH binding sites or existence of metabolites of YM14673. Preincubation with DN1417 (an another TRH analog), cyclo(His-Pro) or methionine-enkephalin did not affect the binding. Affections of YM14673 on TRH binding were observed when cerebral cortical membranes were studied; those were not seen in membranes prepared from hypothalamus, striatum, midbrain, hippocampus, or pons-medulla. The present data indicate that YM14673 exerts its characteristic neuro-pharmacological functions through interacting with TRH binding sites in the brain.

References

Jan 1, 1989·Annals of the New York Academy of Sciences·R J Guiloff
Jan 14, 1986·Biochemical and Biophysical Research Communications·M MoriS Kobayashi
Apr 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·H IshiharaS Kobayashi

❮ Previous
Next ❯

Citations

Aug 27, 2005·Journal of Mass Spectrometry : JMS·A Eugene PekaryAlbert Sattin
May 29, 2004·Peptides·A Eugene PekaryMark Chilingar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.