PMID: 6162459Oct 1, 1980Paper

A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin

The Biochemical Journal
A L Kazim, M Z Atassi

Abstract

A comprehensive synthetic approach for the determination of continuous antigenic sites of proteins is presented. This approach consists of the synthesis of a series of consecutive overlapping peptides that, together, systematically represent the entire primary structure of the protein under study. Its application to the alpha-chain of human haemoglobin afforded, for the first time, a full profile of immunochemically active alpha-chain peptides and enabled the localization of all the major continuous antigenic sites of this haemoglobin subunit.

Citations

May 16, 2006·Immunological Investigations·Takahiro MarutaM Zouhair Atassi
Apr 15, 1994·Annals of the New York Academy of Sciences·J J MarchalonisA B Edmundson
Sep 28, 2007·Molecular Immunology·Behzod Z DolimbekM Zouhair Atassi
Jun 19, 2015·Toxicon : Official Journal of the International Society on Toxinology·M Z Atassi
Dec 8, 2011·Biochemistry·Behzod Z DolimbekM Zouhair Atassi
Mar 18, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·M Zouhair Atassi
Nov 26, 2002·Journal of Molecular Recognition : JMR·John J MarchalonisSamuel F Schluter
Apr 1, 1992·Journal of Protein Chemistry·J J MarchalonisA B Edmundson
Apr 13, 2001·Journal of Molecular Recognition : JMR·J J MarchalonisA B Edmundson
May 1, 1988·Immunological Investigations·S SakataM Z Atassi
Apr 1, 1990·European Journal of Immunology·R G Ulrich, M Z Atassi
Mar 17, 2009·Toxicon : Official Journal of the International Society on Toxinology·M Zouhair Atassi

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