PMID: 9546395Apr 18, 1998Paper

A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins

Cell
J H WeinerR J Turner

Abstract

We report the identification of the proteins encoded by the mttABC operon (formerly yigTUW), which mediate a novel Sec-independent membrane targeting and translocation system in Escherichia coli that interacts with cofactor-containing redox proteins having a S/TRRXFLK "twin arginine" leader motif. A pleiotropic-negative mutant in mttA prevents the periplasmic localization of twin arginine redox enzymes, including nitrate reductase (NapA) and trimethylamine N-oxide reductase (TorA). The mutation also prevents the correct localization of the integral membrane molybdoenzyme dimethylsulfoxide reductase (DmsABC). The DmsA subunit has a twin arginine leader. Proteins with a Sec-dependent leader or which assemble spontaneously in the membrane are not affected by this mutation. MttA, B, and C are members of a large family of related sequences extending from archaebacteria to higher eukaryotes.

References

Oct 1, 1990·Journal of Bacteriology·D SambasivaraoJ H Weiner
Mar 1, 1987·Journal of General Microbiology·D J Latour, J H Weiner
Jan 1, 1986·Methods in Enzymology·B D Lemire, J H Weiner
Sep 1, 1986·Archives of Biochemistry and Biophysics·C FronticelliB P Rosen
Jun 1, 1985·Journal of Bacteriology·P T Bilous, J H Weiner
May 14, 1969·Journal of Molecular Biology·H W Boyer, D Roulland-Dussoix
Jul 1, 1983·Journal of Bacteriology·B D LemireJ H Weiner
Dec 1, 1982·Journal of Bacteriology·B D LemireJ H Weiner
Jul 28, 1995·Science·R D FleischmannJ M Merrick
Jan 1, 1994·Antonie van Leeuwenhoek·A H Stouthamer, B Schink
Mar 1, 1994·Molecular Microbiology·V MéjeanM C Pascal
Nov 1, 1996·Molecular Microbiology·B C Berks
Sep 5, 1997·Science·F R BlattnerY Shao
Dec 31, 1997·Science·A M SettlesR Martienssen
Dec 11, 1997·Cell·F DuongW Wickner

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Citations

Apr 4, 2008·Archives of Microbiology·Isabelle CaldelariFrank Sargent
Dec 2, 2005·Applied Microbiology and Biotechnology·Phatchaneeya ThammawongChatchai Tayapiwatana
Apr 2, 2005·Current Opinion in Microbiology·Ben C BerksFrank Sargent
Apr 9, 2005·Trends in Microbiology·Tracy PalmerBen C Berks
Apr 25, 2003·Biochemical and Biophysical Research Communications·Claire M L BarrettAlbert Bolhuis
Feb 28, 2003·FEBS Letters·Claire M L BarrettColin Robinson
Oct 9, 2002·Journal of Molecular Biology·Erik de LeeuwBen C Berks
Oct 3, 2002·Biochimica Et Biophysica Acta·Laurent Philippot
Jul 9, 1999·Biochimica Et Biophysica Acta·L Philippot, O Højberg
Jul 27, 2002·Journal of Biotechnology·Jan Maarten van DijlJan D H Jongbloed
Oct 18, 2000·FEMS Microbiology Letters·P S SolomonA G McEwan
Feb 14, 2003·FEMS Microbiology Letters·Noémi NógrádyBéla Nagy
Apr 9, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·P Giegé, A Brennicke
Aug 26, 1998·Current Biology : CB·C Stephens
Oct 28, 1998·Trends in Cell Biology·B Martoglio, B Dobberstein
Dec 23, 1998·Trends in Cell Biology·A M Settles, R Martienssen
Mar 24, 1999·Trends in Biochemical Sciences·R E Dalbey, C Robinson
May 14, 1999·Trends in Biochemical Sciences·B J Soltys, R S Gupta
Nov 24, 1999·Trends in Plant Science·J MarienfeldA Brennicke
May 2, 2001·Nature Reviews. Molecular Cell Biology·C Robinson, A Bolhuis
Jan 29, 2000·Molecular Microbiology·B C BerksT Palmer
Apr 28, 2000·European Journal of Biochemistry·S M Musser, S M Theg
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mark C LeakeBen C Berks
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael J TarryBen C Berks
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Felicity AlcockBen C Berks
Nov 2, 2011·The Journal of Biological Chemistry·René van der PloegJan Maarten van Dijl
Feb 9, 2012·The Journal of Biological Chemistry·Neal WhitakerSiegfried M Musser
Mar 9, 2012·The Journal of Biological Chemistry·Sabrina KochTracy Palmer
Jan 16, 2007·The Journal of Biological Chemistry·Danielle Tullman-ErcekGeorge Georgiou

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