PMID: 22362185Mar 1, 2012Paper

A novel animal model of hearing loss caused by acute endoplasmic reticulum stress in the cochlea

Journal of Pharmacological Sciences
Yoshiaki FujinamiTatsuo Matsunaga

Abstract

Many stimuli such as ischemia, hypoxia, heat shock, amino acid starvation, and gene mutation, exhibit a cellular response called endoplasmic reticulum (ER) stress. ER stress induces expression of a series of genes, leading to cell survival or apoptosis. Previously, we found that in an animal model of hearing loss caused by acute mitochondrial dysfunction, several ER stress markers including C/EBP homologous protein were induced in the cochlear lateral wall. To elucidate the mechanism of hearing loss caused by ER stress, we established a novel animal model of hearing loss by perilymphatic perfusion of tunicamycin, an ER stress activator that inhibits N-acetylglucosamine transferases. Subacute and progressive hearing loss was observed at all sound frequencies studied, and stimulation of ER stress marker genes was noted in the cochlea. The outer hair cells were the most sensitive to ER stress in the cochlea. Electron microscopic analysis demonstrated degeneration of the subcellular organelles of the inner hair cells and nerve endings of the spiral ganglion cells. This newly established animal model of hearing loss from ER stress will provide additional insight into the mechanism of sensorineural hearing loss.

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Citations

Jan 13, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ivy Shiue
May 15, 2015·Cell Death & Disease·P Garcia-HuertaC Hetz
May 15, 2013·The American Journal of Pathology·Justin TanPhillip I Bird
Apr 24, 2019·Clinical Pharmacology and Therapeutics·Britt I DrögemöllerBruce C Carleton
Nov 28, 2019·International Journal of Molecular Sciences·Akihiro KishinoTakeshi Oshima
Jun 13, 2020·International Journal of Molecular Sciences·Su Young JungSeung Geun Yeo
Dec 4, 2019·Stem Cell Research & Therapy·Cheng ChengRenjie Chai
Jul 2, 2017·Scientific Reports·Akihiro KishinoTakeshi Oshima
Jan 1, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heather E WheelerLois B Travis

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