A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB

Neuroscience Letters
M IannoneMassimo Fresta

Abstract

The purpose of this investigation was to explore the potentiality of a novel animal model to be used for the in vivo evaluation of the ability of a drug delivery system to promote the passage through the blood-brain barrier (BBB) and/or to improve the brain localization of a bioactive compound. A Tween 80-coated poly-L-lactid acid nanoparticles was used as a model of colloidal drug delivery system, able to trespass the BBB. Tacrine, administered in LiCl pre-treated rats, induces electrocorticographic seizures and delayed hippocampal damage. The toxic effects of tacrine-loaded poly-L-lactid acid nanoparticles (5mg/kg), a saline solution of tacrine (5mg/kg) and an empty colloidal nanoparticle suspension were compared following i.p. administration in LiCl-pre-treated Wistar rats. All the animals treated with tacrine-loaded nanoparticles showed an earlier outcome of CNS adverse symptoms, i.e. epileptic onset, with respect to those animals treated with the free compound (10 min vs. 22 min respectively). In addition, tacrine-loaded nanoparticles administration induced damage of neuronal cells in CA1 field of the hippocampus in all treated animals, while the saline solution of tacrine only in 60% of animals. Empty nanoparticles provid...Continue Reading

References

Mar 17, 2001·Advanced Drug Delivery Reviews·J Kreuter
Feb 16, 2002·Biochemical and Biophysical Research Communications·Giacinto BagettaM Tiziana Corasaniti
Jan 28, 2003·Journal of Child Neurology·Anat Kesler, Aviva Fattal-Valevski
Sep 24, 2004·Advanced Drug Delivery Reviews·Elizabeth C M de Lange
Feb 6, 2008·Expert Opinion on Drug Delivery·Giovanni TosiMaria Angela Vandelli
Dec 9, 2008·Biochimica Et Biophysica Acta·Nicolas WeissPierre-Olivier Couraud
Feb 10, 2009·Current Topics in Medicinal Chemistry·Nunzio DenoraGiuseppe Trapani
Jun 26, 2009·BMC Neurology·William A Banks

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Citations

Oct 7, 2010·Pharmaceutical Research·Inge van RooyEnrico Mastrobattista

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