A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity.

PloS One
K A LefebvreDavid J Marcinek

Abstract

The neurotoxic amino acid, domoic acid (DA), is naturally produced by marine phytoplankton and presents a significant threat to the health of marine mammals, seabirds and humans via transfer of the toxin through the foodweb. In humans, acute exposure causes a neurotoxic illness known as amnesic shellfish poisoning characterized by seizures, memory loss, coma and death. Regular monitoring for high DA levels in edible shellfish tissues has been effective in protecting human consumers from acute DA exposure. However, chronic low-level DA exposure remains a concern, particularly in coastal and tribal communities that subsistence harvest shellfish known to contain low levels of the toxin. Domoic acid exposure via consumption of planktivorous fish also has a profound health impact on California sea lions (Zalophus californianus) affecting hundreds of animals yearly. Due to increasing algal toxin exposure threats globally, there is a critical need for reliable diagnostic tests for assessing chronic DA exposure in humans and wildlife. Here we report the discovery of a novel DA-specific antibody response that is a signature of chronic low-level exposure identified initially in a zebrafish exposure model and confirmed in naturally expose...Continue Reading

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Citations

Oct 24, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lu WangEvan P Gallagher
Aug 22, 2014·Deep-sea Research. Part II, Topical Studies in Oceanography·Luciano F FernandesDonald M Anderson
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Jason A FunkP Darwin Bell
Dec 23, 2015·Journal of the Marine Biological Association of the United Kingdom·Elisa BerdaletHenrik Enevoldsen
Nov 19, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jing JingNina Isoherranen
Sep 8, 2012·International Journal of Microbiology·Joanna Reis Santos-Oliveira, Alda Maria Da-Cruz
Feb 1, 2013·Journal of Pathogens·Aaron Fernstrom, Michael Goldblatt
Nov 1, 2013·BioMed Research International·Praveen P BalgirGurpreet Kaur
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentin A Stonik, Inna V Stonik
Feb 3, 2021·Harmful Algae·Megan E MoriartyChristine K Johnson
May 1, 2021·Pharmacology & Therapeutics·Rebekah PetroffThomas M Burbacher
May 14, 2021·Harmful Algae·Kerri DanilKathi Lefebvre
Jun 25, 2021·American Journal of Veterinary Research·Megan E MoriartyChristine K Johnson

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Methods Mentioned

BETA
ELISA
Dissections
Feature Extraction
PCR
enzyme-linked immunosorbent assays
ELISAs
enzyme-linked immunosorbent assay

Software Mentioned

limma
Bioconductor package p
Bioconductor
. adjust
stats
Agilent Feature Extraction image analysis
ABI Primer Express
BioconductorAgi4×44PreProcess package
Bioconductor kmeans

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