A novel approach to flow quantification in brain arteriovenous malformations prior to enbucrilate embolization: use of insoluble contrast (Ethiodol droplet) angiography

Journal of Neurosurgery
A K WakhlooL N Hopkins

Abstract

Successful therapeutic embolization of arteriovenous malformations (AVMs) of the brain with liquid polymers (glues) requires precise knowledge of highly variable AVM structure and flow velocities and transit times of blood through the AVM nidus. The goal of this study was to improve AVM flow measurement and visualization by the substitution of the insoluble Ethiodol (ethiodized oil) contrast agent for the soluble contrast media normally used in angiographic studies. Before enbucrilate embolization of 24 AVM feeding pedicles in 13 patients, standard contrast medium was superselectively injected into each target pedicle, followed by infusion of 20 microl of Ethiodol microdroplets. Transport of contrast material was assessed using high-speed biplane pulsed digital subtraction angiography (DSA) operating at 15 frames per second. The mean blood flow transit times through AVMs after administration of Ethiodol were found to be approximately half as long as in those measured after injection of soluble contrast materials (0.22 +/- 0.10 seconds compared with 0.46 +/- 0.19 seconds [mean +/- standard deviation]; p < 0.0001). The discrete Ethiodol microdroplets travel with the core flow, more closely approximating the dynamic behavior of en...Continue Reading

References

Sep 1, 1992·Medical Physics·Stephen Rudin, Daniel R Bednarek
Oct 1, 1989·Journal of Thoracic Imaging·J E Takasugi, C Shaw
May 1, 1974·Journal of Biomechanics·Y K Liu, K B Chandran
Jan 1, 1984·Histopathology·K PrathapU Prasad
Oct 1, 1980·Journal of Neurosurgery·H Nornes, A Grip
Feb 1, 1981·Radiology·S J HesselH L ABRAMS
Aug 1, 1993·AJR. American Journal of Roentgenology·S V Lossef, K H Barth

Citations

Jan 4, 2006·Annals of Biomedical Engineering·Baruch B LieberTakami Yamaguchi
Dec 10, 2009·Medical Physics·Baruch B LieberLiliana Cesar
Jul 9, 2013·Computer Methods and Programs in Biomedicine·Tung-Hsin WuTzung-Chi Huang
Feb 5, 2014·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tetsuro SekineShinichiro Kumita
Dec 2, 2005·Journal of Vascular and Interventional Radiology : JVIR·Barbaros E CilFerhun Balkanci
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·Joint Writing Group of the Technology Assessment Committee American Society of Interventional and Therapeutic NeuroradiologW L Young
Aug 8, 2018·AJR. American Journal of Roentgenology·Aichi ChienStephen Kee
Nov 30, 1999·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·S MiyachiJ Yoshida

Methods Mentioned

BETA
sedation
x-ray

Related Concepts

Blood Flow Velocity
Cerebral Angiography
Intracranial Arteriovenous Malformation, Ruptured
Cerebrovascular Circulation
Radiographic contrast media
Diffusion
Embolization, Therapeutic
Ligament-Fimomed
Ethiodized Poppy Seed Oil
Flowmetry

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