A novel approach to normal responder patient with repeated implantation failures--a case report

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Raoul OrvietoBaruch Feldman

Abstract

We describe a case of normal responder patients with repeated implantation failure who was offered the combination of the ultrashort GnRH-ag/ GnRH-ant COH protocol, followed by endometrial injury and a subsequent natural cycle frozen-thawed embryos transfer. The patient conceived following the natural FET cycle that was supported by luteal daily progesterone, with the additional single injection of HCG and GnRH-agonist, on day of ET and 4 days later, respectively. This combined approach seems to be a valuable tool in the armamentarium for treating normal responder patients with repeated implantation failures and should be further examined in large randomized controlled trials.

Associated Clinical Trials

References

Aug 15, 2006·Human Reproduction·E J MargaliothT Eldar-Geva
Jul 12, 2007·Reproductive Biomedicine Online·Stephen R Killick
May 11, 2010·Fertility and Sterility·Raoul OrvietoRavit Nahum
May 21, 2014·Fertility and Sterility·Bruce S ShapiroCynthia Hudson
Nov 12, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Eran ZilberbergRaoul Orvieto

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Citations

Dec 31, 2015·Human Reproduction Update·Roberto MaggiPatrizia Limonta
Mar 15, 2016·Journal of Assisted Reproduction and Genetics·Raoul OrvietoJigal Haas
Dec 7, 2018·Reproductive Biology and Endocrinology : RB&E·Asher BashiriRaoul Orvieto
Jun 15, 2017·Journal of Assisted Reproduction and Genetics·Baruch FeldmanRaoul Orvieto
Jul 13, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shuyi Li, Yanping Li
Aug 11, 2020·Journal of Assisted Reproduction and Genetics·Adva AizerRaoul Orvieto
Mar 13, 2021·Journal of Assisted Reproduction and Genetics·Benjamin P JonesJara Ben Nagi

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