A novel approach to the treatment of central sleep apnea in patients with heart failure.

Herzschrittmachertherapie & Elektrophysiologie
Ralph Augostini

Abstract

Central sleep apnea (CSA) is a common, though often unrecognized, finding in congestive heart failure (HF) patients that is associated with poor quality of life and increased morbidity and mortality. While various treatment strategies, including continuous positive airway pressure (CPAP) therapy, have been devised and tested to treat CSA in HF, none thus far have been proven effective over the long term or been shown to improve survival. Adaptive pressure support servo-ventilation (ASV) is a promising potential new therapy for CSA, but like its predecessor, CPAP, it is often not well tolerated by patients, and results from clinical trials evaluating its long-term effectiveness in reducing morbidity and mortality are still a number of years off. Recently, a new therapy utilizing unilateral transvenous phrenic nerve stimulation has been introduced to treat CSA in HF. As a totally implantable, device-based therapy, it may be better tolerated than CPAP or ASV in HF patients and, thus, improve patient compliance with treatment. Early studies using this therapy have been encouraging, with patients demonstrating significant improvement in major indices of CSA severity.

References

Nov 1, 1988·Pacing and Clinical Electrophysiology : PACE·W W GlennR G Vanderlinden
Dec 1, 1985·Neurosurgery·W W Glenn, M L Phelps
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·P J Hanly, N S Zuberi-Khokhar
Dec 1, 1996·The American Journal of Cardiology·S AndreasH Kreuzer
Apr 8, 1999·Thorax·I WilcoxC E Sullivan
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·D D SinT D Bradley
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·H TeschlerM Berthon-Jones
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Shahrokh Javaheri
Nov 12, 2005·The New England Journal of Medicine·T Douglas BradleyUNKNOWN CANPAP Investigators
Jan 22, 2008·Sleep Medicine·Carmen Carmona-BernalFrancisco Capote
Sep 30, 2009·Respiratory Physiology & Neurobiology·Anthony F DiMarco
Oct 22, 2010·European Journal of Heart Failure·Clemens JilekMichael Arzt
Oct 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Carolyn T BramanteAnthony Weinhaus

❮ Previous
Next ❯

Citations

Mar 12, 2016·International Journal of Cardiology·Susan Joseph, Maria Rosa Costanzo
Oct 23, 2013·Autonomic Neuroscience : Basic & Clinical·Petra Zubin MaslovZeljko Dujic
Feb 18, 2017·Pacing and Clinical Electrophysiology : PACE·Henrik FoxKlaus-Jürgen Gutleben
Oct 22, 2016·Critical Reviews in Food Science and Nutrition·Eric Banan-Mwine DaliriByong H Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved