A novel aspect of NADPH production in ageing Penicillium chrysogenum

Acta Biologica Hungarica
Z VareczaI Pócsi

Abstract

NADPH is involved in many basically important anabolic processes. For a long time, pentose phosphate pathway (PPS) was regarded as the most important source of NADPH in fungi. Here we present evidence of a metabolic switch to an alternative NADPH-producing pathway in ageing Penicillium chrysogenum cultures, which involves NADP+ -specific isocitrate dehydrogenase (NADP+ -ID) rather than PPS enzymes. Considering the main biochemical functions of NADPH, we propose that NADP+ -ID could have deep impact on many physiological processes switched on glucose deprivation including proteinase production or penicillin biosynthesis. We also demonstrate that although the alternative pathway was inferior to PPS when the fungus was grown on well-utilisable carbon sources yet it could have an important role in fatty acid biosynthesis as well as in the maintenance of high intracellular NADPH/NADP+ ratios.

References

Jan 23, 1990·Journal of Theoretical Biology·W Hansberg, J Aguirre
Nov 15, 1988·The Biochemical Journal·I Pócsi, L Kiss
Apr 1, 1983·Journal of General Microbiology·P M BruinenbergW A Scheffers
Jan 23, 2002·Journal of Basic Microbiology·Z NagyS Biró
Apr 18, 2002·Critical Reviews in Biotechnology·Stewart WhiteBrian McNeil
Nov 1, 1960·Biochemical and Biophysical Research Communications·C CHIANG, S G KNIGHT
Aug 12, 2004·Applied Biochemistry and Biotechnology·Tamás EmriIstván Pócsi

❮ Previous
Next ❯

Citations

Dec 21, 2018·Circulation. Cardiovascular Quality and Outcomes·Sripal BangaloreDavid D Waters
Dec 5, 2013·American Journal of Physiology. Endocrinology and Metabolism·S N DankelL Madsen
Aug 1, 2012·PloS One·Sandra Barbosa-da-SilvaMarcia B Aguila

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.