A novel ATX-S10(Na) photodynamic therapy for human skin tumors and benign hyperproliferative skin

Photodermatology, Photoimmunology & Photomedicine
Hidetoshi TakahashiHajime Iizuka

Abstract

Photodynamic therapy (PDT) is a promising treatment for various skin tumors and other skin diseases. We investigated the potential therapeutic effects of PDT using ATX-S10(Na) ointment and a diode laser in mouse skin models of experimental skin tumors as well as transplanted human samples of superficial skin tumors and lesional psoriatic skin. ATX-S10(Na) ointment (1% w/v) was introduced into tape-stripped mouse skin, transplanted squamous cell carcinoma (SCC) samples and human skin diseases after topical application, then PDT was performed. ATX-S10(Na) ointment (1% w/v) was introduced effectively into tape-stripped mouse skin and transplanted SCC samples after topical application, but was not detected after 48 h, as assessed by fluorescence microscopy. PDT, using 1% ATX-S10(Na) ointment and diode laser (50 J/cm(2)), was found to decrease epidermal thickness in 12-0-tetradecanoylphorbol-13-acetate (TPA)-treated mouse skin by 6 days. PDT with 1% ATX-S10(Na) ointment and diode laser (150 J/cm(2)) was also effective for transplanted SCC, and tumors were eliminated by 6 weeks. PDT against Bowen disease, basal-cell carcinoma, and psoriasis xenografts onto SCID mice also showed marked suppression of tumor growth and cell proliferatio...Continue Reading

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Citations

Aug 2, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S Fleskens, M R Scheltinga
May 25, 2005·Photomedicine and Laser Surgery
Jun 16, 2005·Photomedicine and Laser Surgery
Sep 8, 2005·Photomedicine and Laser Surgery
Sep 18, 2007·Journal of Dermatological Science·Hidetoshi TakahashiHajime Iizuka
May 10, 2008·Clinical Orthopaedics and Related Research·Ken TakedaToshifumi Ozaki
Feb 24, 2006·Radiation Research·Manabu Kinoshita, Kullervo Hynynen

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