A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease.

PLoS Pathogens
David E GreenbergSteven M Holland

Abstract

Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. We identified a novel gram-negative rod in excised lymph nodes from a patient with CGD. Gram-negative rods grew on charcoal-yeast extract, but conventional tests could not identify it. The best 50 matches of the 16S rRNA (using BLAST) were all members of the family Acetobacteraceae, with the closest match being Gluconobacter sacchari. Patient serum showed specific band recognition in whole lysate immunoblot. We used mouse models of CGD to determine whether this organism was a genuine CGD pathogen. Intraperitoneal injection of gp91(phox -/-) (X-linked) and p47 (phox -/-) (autosomal recessive) mice with this bacterium led to larger burdens of organism recovered from knockout compared with wild-type mice. Knockout mouse lymph nodes had histopathology that was similar to that seen in our patient. We recovered organisms with 16S rRNA sequence identical to the patient's original isolate from the infected mice. We identified a novel gram-negative rod from a patient with CGD. To confirm its pathoge...Continue Reading

References

Sep 1, 1995·The Journal of Experimental Medicine·S H JacksonS M Holland
Oct 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Lekstrom-HimesJ I Gallin
Jan 1, 1993·Journal of Computer Assisted Tomography·S W Atlas
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Jan 30, 1999·Systematic and Applied Microbiology·M SieversW Ludwig
Feb 24, 2001·Ryōikibetsu shōkōgun shirīzu·M Iwata, H Nunoi
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Sereti, S M Holland
Jul 30, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan E DormanSteven M Holland
Feb 25, 2003·The Journal of Infectious Diseases·Shireen V GuideSteven M Holland
Apr 12, 2003·Letters in Applied Microbiology·E J BartowskyP A Henschke
Mar 12, 2004·Journal of Applied Microbiology·A GonzálezJ M Guillamón
Apr 2, 2004·The Journal of General and Applied Microbiology·Apisit SeearunruangchaiYuzo Yamada
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard W SnyderJoshua H Lipschutz

❮ Previous
Next ❯

Citations

Dec 7, 2013·Journal of Clinical Immunology·Manish RameshCharlotte Cunningham-Rundles
Sep 11, 2007·Journal of Bacteriology·David E GreenbergSteven M Holland
Nov 30, 2007·Emerging Infectious Diseases·Anne GoubyEstelle Jumas-Bilak
Dec 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Sean-Paul Nuccio, Andreas J Bäumler
Jan 9, 2008·Antimicrobial Agents and Chemotherapy·Clemente I MonteroPatrick R Murray
May 30, 2008·Emerging Infectious Diseases·Fadi BittarJean-Marc Rolain
Apr 30, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David E GreenbergJohn J Lipuma
Jun 12, 2009·Annual Review of Microbiology·Ludmila ChistoserdovaMary E Lidstrom
Sep 10, 2010·Journal of Clinical Microbiology·Corentine AlauzetHélène Marchandin
Sep 21, 2010·Applied and Environmental Microbiology·Elena CrottiDaniele Daffonchio
Jun 9, 2009·Clinical Reviews in Allergy & Immunology·Steven M Holland
Jul 12, 2012·The Journal of Infectious Diseases·David E GreenbergSteven M Holland
Aug 25, 2009·Current Infectious Disease Reports·Iain P Fraser
Jul 4, 2012·Journal of Clinical Immunology·John M ChaseJoseph A Church
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Elizabeth M KangHarry L Malech
Nov 11, 2008·The Lancet Infectious Diseases·Anne-Marie LoweMarcel A Behr
Aug 5, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kelly L BrownDavid P Speert
Jul 22, 2008·La Revue de médecine interne·M J StasiaI Durieu
Jun 19, 2008·The Journal of Infection·F C Rodríguez LópezM Casal
Mar 10, 2016·Current Gastroenterology Reports·Mathieu UzzanCharlotte Cunningham-Rundles
Nov 17, 2006·Environmental Microbiology·Michael Y Galperin
Jan 26, 2008·British Journal of Haematology·Reinhard A Seger
Dec 9, 2014·Biotechnology Advances·Natsaran SaichanaJitka Frebortova
Mar 5, 2015·Journal of Basic Microbiology·Veronica Massena Reis, Kátia Regina dos Santos Teixeira
Mar 4, 2014·PloS One·Sandra AppeltMichel Drancourt
Jan 1, 2009·Expert Review of Clinical Immunology·Sergio D Rosenzweig
Jun 27, 2017·The Pediatric Infectious Disease Journal·Erick F MayerJasmeen Dara
Dec 21, 2011·Infection and Immunity·Kol A ZaremberDavid E Greenberg
May 3, 2006·PLoS Pathogens·David Fredricks, Lalita Ramakrishnan
Jun 13, 2006·Nature Reviews. Microbiology
Nov 16, 2010·Current Opinion in Hematology·Reinhard A Seger
Nov 4, 2006·International Journal of Systematic and Evolutionary Microbiology·David E GreenbergAdrian M Zelazny
Oct 4, 2012·Expert Review of Anti-infective Therapy·Josef Ben-AriBaruch Wolach
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica ChuJohn I Gallin
May 11, 2018·Journal of the Pediatric Infectious Diseases Society·Nicholas BennettChrista Zerbe
Aug 18, 2020·Pediatric Health, Medicine and Therapeutics·Benjamin T PrinceSteven M Holland
Jul 18, 2020·Frontiers in Pediatrics·Tayfun Güngör, Robert Chiesa

❮ Previous
Next ❯

Datasets Mentioned

BETA
AF127412

Methods Mentioned

BETA
biopsy
16S sequencing
electron microscopy
protein assay

Software Mentioned

BLAST
Lasergene
PHYLIP
BLASTn )
TreeView
DNADIST
NEIGHBOR
CLUSTAL
DNASTAR

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

© 2022 Meta ULC. All rights reserved