A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations

NeuroImage
Aaron B SimonR B Buxton

Abstract

Calibrated blood oxygenation level dependent (BOLD) imaging is a multimodal functional MRI technique designed to estimate changes in cerebral oxygen metabolism from measured changes in cerebral blood flow and the BOLD signal. This technique addresses fundamental ambiguities associated with quantitative BOLD signal analysis; however, its dependence on biophysical modeling creates uncertainty in the resulting oxygen metabolism estimates. In this work, we developed a Bayesian approach to estimating the oxygen metabolism response to a neural stimulus and used it to examine the uncertainty that arises in calibrated BOLD estimation due to the presence of unmeasured model parameters. We applied our approach to estimate the CMRO2 response to a visual task using the traditional hypercapnia calibration experiment as well as to estimate the metabolic response to both a visual task and hypercapnia using the measurement of baseline apparent R2' as a calibration technique. Further, in order to examine the effects of cerebral spinal fluid (CSF) signal contamination on the measurement of apparent R2', we examined the effects of measuring this parameter with and without CSF-nulling. We found that the two calibration techniques provided consiste...Continue Reading

References

Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Jan 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J A DetreA P Koretsky
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Herscovitch, M E Raichle
Sep 1, 1974·Stroke; a Journal of Cerebral Circulation·R L GrubbM M Ter-Pogossian
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S P Yang, J A Krasney
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy, E M Haacke
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I HorvathA C McLaughlin
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Jun 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy, E M Haacke
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·T L DavisB R Rosen
Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy
May 15, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E C WongL R Frank
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·J P WansapuraW S Ball
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·J A ChalelaJ A Detre
May 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I KidaF Hyder
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverD Ress
Apr 3, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W M SpeesJ J Ackerman
Jul 5, 2003·Physiological Reviews·Amy G TsaiMarcos Intaglietta
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M van Zijl
Oct 22, 2004·Nature Reviews. Neuroscience·Luigi ZeccaRobert R Crichton
Dec 14, 2004·NeuroImage·Thomas T Liu, Eric C Wong
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinghua WangR Todd Constable
Mar 10, 2005·IEEE Transactions on Medical Imaging·Douglas C NollBradley P Sutton
Jun 23, 2005·Journal of Magnetic Resonance Imaging : JMRI·Hanzhang LuPeter C M van Zijl
Mar 15, 2006·NeuroImage·Khaled RestomThomas T Liu
Dec 28, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiang He, Dmitriy A Yablonskiy
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jason M ZhaoPeter C M van Zijl
Dec 7, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bojana StefanovicAfonso C Silva
Jan 29, 2008·Cerebral Cortex·Bruno WeberNikos K Logothetis
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang Lu, Yulin Ge
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xiang He, Dmitriy A Yablonskiy
Apr 8, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Jean Chen, G Bruce Pike
Sep 16, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Feng XuHanzhang Lu
Oct 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·John D DicksonRichard E Ansorge
Jun 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D S BolarE Adalsteinsson
Jun 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Audrey P FanElfar Adalsteinsson
Jul 26, 2011·Journal of Magnetic Resonance·John D DicksonDmitriy A Yablonskiy

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Citations

Jan 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yayan YinJia-Hong Gao
Feb 11, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yayan YinJie Lu

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