A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury

The Journal of Trauma
Angel DelgadoJohn B Holcomb

Abstract

This study evaluated the efficacy of a biologic hemostatic fibrin patch (FP) to control coagulopathic bleeding and prevent death in a porcine model of severe liver injury with hemodilution and hypothermia. Coagulopathy was produced in swine by exchanging 60% of the animals' circulating blood volume with Hextend and lowering the core temperature to 32.0 degrees C +/- 0.5 degrees C. A grade V liver injury was induced and allowed to bleed freely for 30 seconds (pretreatment blood loss). Animals were randomly divided into three treatment groups: hepatic packing (HP) using laparotomy sponges, FP application plus HP, or placebo patch (PP) application plus HP. Animals were resuscitated to 80% of the preinjury mean arterial pressure. Core temperature, mean arterial pressure, and survival were monitored for 1 hour postinjury. Packs were removed from the animals that survived to 1 hour and they were monitored for an additional hour. Coagulopathy was confirmed by significant increases (p < 0.01) in prothrombin time, activated partial thromboplastin time, and activated clotting time in preinjury measurements as compared with baseline values. Pretreatment blood loss was not different among the groups. However, significant (p < 0.01) differe...Continue Reading

References

Dec 1, 1992·The Journal of Trauma·A F BernabeiJ S Bender
Sep 1, 1987·The Journal of Trauma·G K LunaM R Oreskovich
Sep 1, 1987·The Journal of Trauma·G J JurkovichP W Curreri
Feb 1, 1995·The Australian and New Zealand Journal of Surgery·K A GunningS A Deane
Jun 27, 2001·The Journal of Trauma·J G TyburskiA M Carlin
Sep 6, 2001·The Journal of Trauma·U MartinowitzM Lynn
Jul 12, 2003·The Journal of Trauma·Jana B A MacLeodMary Murtha
Feb 26, 2004·Critical Care Clinics·Martin A Schreiber
Jun 22, 2005·Clinical Pharmacokinetics·Cornelius Jungheinrich, Thomas A Neff
Aug 13, 2005·The Journal of Trauma·Harold G KlemckeAnthony E Pusateri
Nov 18, 2005·Current Opinion in Critical Care·Martin A Schreiber
Oct 6, 2006·Current Opinion in Anaesthesiology·Peter J Safar, Samuel A Tisherman

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Citations

Aug 13, 2015·Intensive Care Medicine Experimental·Frank HildebrandHans-Christoph Pape
Dec 18, 2013·The Journal of Surgical Research·Christian ZentaiOliver Grottke
May 11, 2010·The Journal of Surgical Research·Richard W HutchinsonJames Hart
Nov 6, 2009·American Journal of Surgery·Grant BochicchioThomas Scalea
Aug 5, 2008·The Journal of Surgical Research·Weiwei DingJieshou Li
Jun 4, 2015·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·A Navarro, A Brooks
Sep 29, 2011·Biomaterials·Alexander M HarmonTim R Muench
Sep 30, 2016·Revista do Colégio Brasileiro de Cirurgiões·Frederico Michelino DE OliveiraClóvis Antônio Lopes Pinto
Jun 9, 2016·Revista do Colégio Brasileiro de Cirurgiões·Frederico Michelino de OliveiraClóvis Antônio Lopes Pinto
May 4, 2011·Acta Cirúrgica Brasileira·Dalmer Faria FreireDjalma José Fagundes
Nov 30, 2018·PloS One·Ujwal R YanalaMark A Carlson
Sep 11, 2009·Current Opinion in Critical Care·Chitra N Sambasivan, Martin A Schreiber
Jun 23, 2018·Surgical Neurology International·Hitoshi KayataniKazuhiko Nozaki
Sep 9, 2010·Expert Review of Medical Devices·Henry T Peng, Pang N Shek
Apr 30, 2017·The Journal of Trauma and Acute Care Surgery·Kiavash R KokoJoshua P Hazelton
Nov 23, 2017·Advanced Materials·DaShawn A HickmanAnirban Sen Gupta
Aug 24, 2012·The Journal of Trauma and Acute Care Surgery·Françoise ArnaudRichard McCarron
Dec 17, 2010·Expert Review of Medical Devices·Stephanie D GordyMartin A Schreiber
Feb 2, 2021·Frontiers in Veterinary Science·Thomas H EdwardsAnthony E Pusateri
Jun 4, 2021·International Journal of Biological Macromolecules·Xiaojie SunChao Feng

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