A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study

International Journal of Molecular Sciences
Satoshi WashinoTomoaki Miyagawa

Abstract

Background: Vanin-1 is a novel acute kidney injury (AKI) biomarker that has not been clinically investigated as a biomarker for obstructive nephropathy. This study investigated the diagnostic value of vanin-1 as a biomarker for adult obstructive nephropathy by comparing it to existing AKI biomarkers. Methods: A total of 49 patients, 21 controls, and 28 hydronephrosis (HN) cases were assessed. AKI biomarkers in bladder (BL) urine and renal pelvic (RP) urine in the HN group were compared to each BL marker in the control group. In a subgroup of cases receiving interventions for obstructive nephropathy, the BL values of each biomarker were assessed after the intervention. Results: RP vanin-1 levels were significantly higher while BL vanin-1 levels were marginally higher in the HN group than in the control group. The area under the receiver operating characteristics curve values for RP and BL vanin-1 were 0.9778 and 0.6386, respectively. In multivariate analyses, BL vanin-1 and N-acetyl-β-D-glucosaminidase (NAG), but not kidney injury molecule-1 (KIM-1) or neutrophil gelatinase-associated lipocalin (NGAL), were independent factors for predicting the presence of HN. In cases receiving interventions, vanin-1 decreased significantly fr...Continue Reading

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Citations

Nov 7, 2019·Phytotherapy Research : PTR·Alaa A GheitaSanaa A Kenawy
Aug 6, 2020·International Journal of Molecular Sciences·Satoshi WashinoTomoaki Miyagawa
Aug 14, 2019·International Journal of Molecular Sciences·Roberta BartucciYkelien L Boersma
Aug 8, 2020·The Journal of Clinical Hypertension·Yuanyuan Zhang, Xianhui Qin
Nov 17, 2020·American Journal of Physiology. Renal Physiology·Kerstin UnterschemmannManuel Grundmann
Feb 25, 2021·Infectious Diseases and Therapy·Hongxiang LuJianxin Jiang
Mar 4, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Grażyna KrzemieńAgnieszka Szmigielska

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Methods Mentioned

BETA
urine collection
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
GraphPad
GraphPad Prism

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