A novel biomarker for anti-androgenic activity in placenta reveals risks of urogenital malformations

Reproduction : the Official Journal of the Society for the Study of Fertility
Juan P ArrebolaNicolas Olea

Abstract

It has been hypothesized that the rise in male reproductive disorders over recent decades may at least be partially attributable to environmental factors, including chemical exposures, but observed associations with single chemicals were rather weak. The aim of this case-control study was to explore the relationship between exposure to mixtures of (anti-)androgenic chemicals during pregnancy and the risk of cryptorchidism and/or hypospadias in offspring, using the total effective xenobiotic burden of anti-androgens (TEXB-AA) as a biomarker. A subsample of 29 cases (16 of cryptorchidism, 12 of hypospadias, and one of both disorders) and 60 healthy controls was nested in a cohort of male newborns recruited between October 2000 and July 2002. The (anti-)androgenic activity of placenta samples collected at delivery was assessed using TEXB-AA biomarker, combined with a bioassay-directed fractionation protocol that separated endogenous hormones from most (anti-)androgenic chemicals by normal-phase HPLC. The bioassay measures the androgen-induced luciferase activity and the inhibition of this pathway by (anti-)androgens. First, we collected 27 HPLC fractions in each placenta extract, which were all tested in the bioassay. The multivar...Continue Reading

References

Jan 1, 1974·The Journal of Clinical Endocrinology and Metabolism·P K Siiteri, J D Wilson
May 4, 2001·Environmental Health Perspectives·J PayneA Kortenkamp
Dec 1, 1964·Archives of Disease in Childhood·C G SCORER
Jul 29, 2004·Cancer Causes & Control : CCC·Jesús m Ibarluzea JmNicolas Olea
Nov 9, 2004·Environmental Health Perspectives·Frank H PierikRob F A Weber
Aug 5, 2005·Environmental Health Perspectives·Shanna H SwanUNKNOWN Study for Future Families Research Team
Mar 15, 2006·Reproductive Toxicology·P CarboneI Figà-Talamanca
Jul 13, 2006·Environmental Health Perspectives·Ida N DamgaardUNKNOWN Nordic Cryptorchidism Study Group
Dec 13, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Ieuan A Hughes, Asma Deeb
Mar 24, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·R P Amann, D N R Veeramachaneni
Oct 17, 2007·Environmental Health Perspectives·Katharina Maria MainJorma Toppari
Mar 5, 2008·International Journal of Andrology·Vickie S WilsonL Earl Gray
May 27, 2008·Human Reproduction·Françoise Brucker-DavisUNKNOWN Cryptorchidism Study Group from Nice Area
Aug 20, 2009·Environmental Health : a Global Access Science Source·Julie R PalmerRobert N Hoover
Jun 15, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Katharina M MainJorma Toppari
Jul 8, 2010·Environment International·Juan P ArrebolaPiedad Martin-Olmedo
Mar 16, 2011·Nature Reviews. Urology·Katrine BayNiels E Skakkebæk
Apr 13, 2013·International Journal of Cancer. Journal International Du Cancer·Britton TrabertOlof Akre
Jan 18, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Andreas KortenkampSibylle Ermler

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Citations

Oct 21, 2016·Environmental Research·Juan P ArrebolaLuis A Mercado
Dec 15, 2016·Journal of Epidemiology and Community Health·Martin Wagner
Jun 28, 2017·Nature Reviews. Urology·Jason K GurneyDiana Sarfati
Jul 20, 2018·International Journal of Environmental Health Research·Melanie C BuserHana R Pohl
Jan 6, 2021·Environment International·Maryam Zare JeddiRobert Pasanen-Kase
Oct 18, 2020·Environment International·Anne Marie VinggaardMarja Lamoree
Jan 15, 2021·Reproductive Toxicology·Andrea Rodríguez-CarrilloMariana F Fernández

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