A novel biosensor based on Au@Ag core-shell nanoparticles for sensitive detection of methylamphetamine with surface enhanced Raman scattering

Talanta
Kang MaoZhugen Yang

Abstract

We describe a novel biosensing strategy for sensitive detection of methylamphetamine (MAMP) based on surface enhanced Raman scattering (SERS) by the mediation of spacing between 4-mercaptobenzoic acid (4-MBA) labeled Au@Ag core-shell nanoparticles (Au@Ag). To achieve a favorable SERS substrate, Au@Ag shell-core nanoparticle was synthesized with seeds growth method and well characterized by SEM, TEM and UV-vis spectrometer. The uniform Au@Ag shows an excellent dispersion ability for SERS detection. Under the optimized conditions, the novel biosensor shows a good logarithm linear correlation with the concentration of MAMP ranging from 0.5 ppb to 40 ppb (R2 = 0.986), with a limit of detection at 0.16 ppb of MAMP (3σ). Furthermore, our biosensors hold an excellent selectivity, demonstrated by the negligible interference from the detection of other illicit drugs and metabolites. The concentrations determined with our biosensor from spiked MAMP in human urine sample fell within the same range with the results from mass spectrometry. This indicates that our sensor has a clear potential for the rapid detection of illicit drug in real samples.

References

Apr 30, 2008·Chemical Society Reviews·Janina KneippKatrin Kneipp
Aug 15, 2015·Science·Stephanie GalanieChristina D Smolke
Nov 26, 2015·Biosensors & Bioelectronics·Wenjing YanJianhao Zhang
Mar 9, 2017·Chemical Reviews·Jian-Feng LiZhong-Qun Tian
Aug 23, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Neus FeliuRamon Alvarez-Puebla

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Citations

May 7, 2020·Frontiers in Chemistry·Zhengdi WangMin Wei
Dec 8, 2019·Sensors·Muqsit Pirzada, Zeynep Altintas

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