A Novel Biosensor Based on Molybdenum Disulfide (MoS2 ) Modified Porous Anodic Aluminum Oxide Nanochannels for Ultrasensitive microRNA-155 Detection.

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Songlong JiaoJun Lv

Abstract

Artificial photoresponsive nanochannels have attracted widespread attention because of their capacity to achieve ion transport through light modulation. Herein, a biosensor for ultrasensitive miRNA-155 detection is devised based on molybdenum disulfide (MoS2 ) modified porous anodic aluminum oxide (AAO) photoresponsive nanochannels by atomic layer deposition (ALD). According to the optimized experimental results, when the cycles of ALD, the wavelength, and the power of the excitation laser are 70 cycles, 450 nm, and 80 mW, respectively, the most supreme photocurrent performance of these photoresponsive nanochannels are obtained. AAO nanochannels modified with MoS2 can work as a photoelectrochemical (PEC) biosensor by generating photoexcitation current; what is more, the high channel density in AAO can magnify the ion current signal response effectively by aggrandizing the flux of electroactive species. By using AAO photoresponsive nanochannels with an average diameter of 150 nm as PEC biosensor, an ultrasensitive detection record ranging from 0.01 fM to 0.01 nM with a detection limit of 3 aM can be achieved. This work not only proposes a simple method for manufacturing semiconductor photoresponsive nanochannels, but also exhibi...Continue Reading

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Citations

Apr 10, 2021·ACS Applied Materials & Interfaces·Liu ShiGenxi Li
May 25, 2021·ACS Applied Materials & Interfaces·Shi-Qi ChengHaibing Li
Jan 21, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang LiJin-Ping Ao

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