PMID: 2495771May 1, 1989Paper

A novel biosynthesis of medium chain length alpha-ketodicarboxylic acids in methanogenic archaebacteria

Archives of Biochemistry and Biophysics
Robert H White

Abstract

Gas chromatographic-mass spectrometric analysis on the distribution of alpha-ketodicarboxylic acids in various bacteria determined that alpha-ketoglutarate and alpha-ketoadipate are widely distributed in all the bacteria examined, whereas alpha-ketopimelate and alpha-ketosuberate are found only in the methanogenic archaebacteria. Labeling experiments with stable isotopes indicated that each of these acids arises from alpha-ketoglutarate by repeated alpha-ketoacid chain elongation. The final product in this series of reactions, alpha-ketosuberate, serves in the methanogenic bacteria as the biosynthetic precursor to the 7-mercaptoheptanoic acid portion of 7-mercaptoheptanoylthreonine phosphate, a methanogenic coenzyme.

References

Nov 1, 1977·Applied and Environmental Microbiology·W H SiegelR W Bernlohr
Dec 10, 1975·Journal of Chromatography·U LangenbeckK P Dieckmann
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K M NollR S Wolfe
May 1, 1983·Journal of Bacteriology·H N WestfallD E Peterson
Jul 1, 1984·Applied and Environmental Microbiology·D R LovleyJ G Ferry

❮ Previous
Next ❯

Citations

Jan 1, 1992·Progress in Biophysics and Molecular Biology·G Wächtershäuser
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G Wächtershäuser
Feb 19, 2008·Extremophiles : Life Under Extreme Conditions·Michaela FalbDieter Oesterhelt
Dec 22, 2007·Annals of the New York Academy of Sciences·Laura L Grochowski, Robert H White
Jul 1, 2014·Biochemistry·Danielle MillerRobert H White
Oct 6, 1997·Archives of Biochemistry and Biophysics·B Solow, R H White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.