A novel bottom-up process to produce drug nanocrystals: controlled crystallization during freeze-drying

Journal of Controlled Release : Official Journal of the Controlled Release Society
Hans de WaardHenderik W Frijlink

Abstract

To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze drying which allows for the production of nanocrystalline particles was developed: "controlled crystallization during freeze drying". This novel process could strongly increase the dissolution behavior of fenofibrate. For example at a drug load of 30% w/w, 80% of the drug dissolved within 10 min from tablets prepared from the controlled crystallized dispersions, while from tablets prepared from the physical mixture only 50% was dissolved after 120 min. Furthermore it was found that faster freezing or using a solution with a lower water/tertiary butyl alcohol (TBA) ratio resulted in faster dissolution, indicating that the crystalline dispersions contained smaller crystals. Crystallization of the drug could occur during freezing or during drying. When crystallization occurs during freezing, faster freezing or using solutions with a lower water/TBA ratio results in the formation of more nuclei and consequently smaller crystals. When crystallization occurs during drying, faster freezing or using solutions with a higher water/TBA ratio results in the formation of smaller solvent crystals and therefore smaller interstitial spaces whic...Continue Reading

References

Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Oct 9, 1999·Journal of Pharmaceutical Sciences·T KristmundsdóttirH Thormar
Aug 15, 2002·International Journal of Pharmaceutics·Marazban SarkariKeith P Johnston
Feb 21, 2003·Biomaterials·DongZhi HouChangHong Zhu
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Aug 10, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bhaskar ChauhanAnant Paradkar
Sep 1, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cornelia M Keck, Rainer H Müller
Nov 25, 2005·Pharmaceutical Research·Boris Y ShekunovRobert Huff

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Citations

Apr 23, 2013·Colloids and Surfaces. B, Biointerfaces·Pradum Pundlikrao IgeSurendra G Gattani
Jun 12, 2013·International Journal of Pharmaceutics·Chris Brough, R O Williams
Jul 24, 2013·International Journal of Pharmaceutics·Baoyan ZuoZhonggui He
Oct 12, 2013·Biotechnology Advances·Shutao Guo, Leaf Huang
May 25, 2011·Pharmaceutical Research·Hans de WaardHenderik W Frijlink
Nov 19, 2010·Pharmaceutical Research·Hans de WaardWouter L J Hinrichs
Oct 25, 2014·Drug Development and Industrial Pharmacy·Shashank JainSenshang Lin
May 10, 2011·Drug Development and Industrial Pharmacy·Zhi-Liang ZhangJian-Feng Chen
Aug 31, 2013·Drug Development and Industrial Pharmacy·Jardin Leleux, Robert O Williams
Sep 8, 2010·Drug Development and Industrial Pharmacy·Lili ZhangXing Tang
Apr 25, 2012·Drug Development and Industrial Pharmacy·Weibin DengMichael A Repka
Oct 10, 2013·Drug Development and Industrial Pharmacy·Mohammad A AzadRajesh Davé
Feb 26, 2013·Journal of Pharmaceutical Sciences·Jaime SalazarJan P Möschwitzer
Aug 8, 2014·Journal of Pharmaceutical Sciences·William Wei Lim ChinRajeev Gokhale
Jan 22, 2013·International Journal of Pharmaceutics·Biswadip SinhaJan P Möschwitzer
Jan 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jianjun ZhangShuai Qian
Jan 23, 2016·Advances in Colloid and Interface Science·Waseem Kaialy, Maen Al Shafiee
May 7, 2013·Current Opinion in Solid State & Materials Science·Bo Sun, Yoon Yeo
Sep 15, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Meimei ZhangRobert O Williams
Mar 24, 2016·Acta Pharmaceutica Sinica. B·Yi LuWei Wu
Jan 12, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jaime SalazarJan P Möschwitzer
Nov 29, 2011·International Journal of Pharmaceutics·Guangpu LiuHongxiang Lou
Sep 20, 2011·International Journal of Pharmaceutics·Jaime SalazarJan P Möschwitzer
Aug 3, 2010·International Journal of Pharmaceutics·Ranjita Shegokar, Rainer H Müller
Mar 9, 2010·Drug Discovery Today·Huabing ChenJinming Gao
Jul 28, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hans de WaardHenderik W Frijlink
May 2, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hany S M AliToni Brook
Mar 25, 2016·Colloids and Surfaces. B, Biointerfaces·Jeong-Joo ParkBeom-Jin Lee
Sep 19, 2015·International Journal of Pharmaceutics·Chun LiuFeng Qian
Jan 3, 2013·Experimental Dermatology·Lutz FranzenMaike Windbergs
Jan 19, 2016·CrystEngComm·L M DwyerA S Myerson
Jul 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Liang YangHyo-Kyung Han
Aug 21, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yancai WangDianrui Zhang
Jun 15, 2014·International Journal of Pharmaceutics·Xi HuYanjiao Wang
Feb 8, 2011·International Journal of Pharmaceutics·Wei LiLiang Fang
Feb 25, 2014·International Journal of Pharmaceutics·Seyed Salman Razavi RohaniMohsen Tafaghodi
Oct 29, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Réka AngiFerenc Darvas
May 22, 2016·Drug Delivery and Translational Research·Yaya LeiWenping Wang
Jun 9, 2016·Expert Opinion on Drug Delivery·Carin Ru Shan SiowLai Wah Chan

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