PMID: 11916166Mar 28, 2002Paper

A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes

Human Immunology
M DeshpandeDebashis Mitra

Abstract

The primary transcript of the human CD28 gene in T lymphocytes, encoding for a costimulatory molecule, is known to undergo alternative splicing, and different small sets of variant isoforms have been reported. This report presents the novel simultaneous presence of eight different mRNA isoforms, all observed together in normal human T cells; this is an interesting finding in the study of CD28 mRNA structural variants. A similar pattern was found in a total of four individuals. In addition, we also report the occurence and sequence of a new CD28 mRNA isoform, one of the above eight, which is a novel variant generated by the use of a new combination of splice donor and acceptor sites.

References

May 21, 1999·Biochemical and Biophysical Research Communications·G MagistrelliY Delneste
Nov 11, 1999·European Journal of Immunology·G MagistrelliY Delneste
Jun 1, 2000·Cellular Immunology·M K OaksA J Tector

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Citations

Feb 21, 2004·Journal of Neuroimmunology·Suzy M TeutschGraeme J Stewart
Apr 7, 2004·The Journal of Experimental Medicine·Sebastian A MikolajczakAtsuo Ochi
Sep 2, 2010·Human Immunology·Manisha DeshpandeAnish Sen Majumdar
Jul 12, 2018·Journal of Clinical Laboratory Analysis·Erika Fabiola López-VillalobosEdith Oregon-Romero
Nov 22, 2016·Clinical & Translational Immunology·Xu Min LuoXiongbiao Wang

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