PMID: 20647688Jul 22, 2010Paper

A novel chemoattractant lectin, karatoxin, from the dorsal spines of the small scorpionfish Hypodytes rubripinnis

Journal of Pharmacological Sciences
Mitsuko ShinoharaH Sakuraba

Abstract

A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by D-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances.

References

Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jarrod E Church, Wayne C Hodgson

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Citations

May 6, 2015·Toxins·Rebekah Ziegman, Paul Alewood

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