A novel choline-sensitive nicotinic receptor subtype that mediates enhanced GABA release in the chick ventral lateral geniculate nucleus

Neuroscience
J-Z Guo, V A Chiappinelli

Abstract

Nicotinic acetylcholine receptors modulate the release of GABA, glutamate, acetylcholine and dopamine in the brain. Here we describe a novel choline-sensitive nicotinic acetylcholine receptor that mediates enhanced GABA release in the chick ventral lateral geniculate nucleus. Whole-cell recordings in slices demonstrated that choline (0.03-10 mM), generally considered an alpha7-selective agonist, and carbachol (3-300 microM), a non-selective cholinergic agonist, both increased the frequency of spontaneous GABAergic events in ventral lateral geniculate nucleus neurons. Tetrodotoxin (0.5 microM) partially reduced responses to carbachol, but eliminated responses to choline. During long-term (5 min) exposure to choline the GABA enhancement was maintained until choline was washed out. Choline (300 microM) enhanced the frequency of spontaneous GABAergic events by 4.28-fold in control artificial cerebrospinal fluid. This choline-mediated enhancement was significantly reduced by the following nicotinic acetylcholine receptor antagonists: 1 microM dihydro-beta-erythroidine (1.49-fold increase, P<0.001), 1 microM methyllycaconitine (1.53-fold, P<0.001) and 0.2 microM alpha-conotoxin ImI (1.84-fold, P<0.001). In contrast, no significant ch...Continue Reading

References

Mar 22, 1989·The Journal of Comparative Neurology·E M SorensonV A Chiappinelli
Sep 22, 1989·The Journal of Comparative Neurology·R H Granda, W J Crossland
Mar 10, 1984·The Journal of Comparative Neurology·D Ehrlich, R Mark
Jan 1, 1995·Annual Review of Physiology·D S McGehee, L W Role
Feb 1, 1997·Trends in Neurosciences·S Wonnacott
Nov 19, 1997·Progress in Neurobiology·C GottiF Clementi
Mar 28, 1998·The European Journal of Neuroscience·M AlkondonE X Albuquerque
Apr 15, 1999·Annual Review of Neuroscience·A B MacDermottS A Siegelbaum
Aug 24, 1999·The European Journal of Neuroscience·M ZaninettiM Raggenbass
Apr 20, 2000·European Journal of Pharmacology·S VailatiC Gotti
Jun 29, 2000·Annual Review of Biochemistry·J M McIntoshB M Olivera
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A B ElgoyhenJ Boulter

❮ Previous
Next ❯

Citations

Feb 25, 2005·Behavioral Neuroscience·Christopher M ButtJerry A Stitzel
Oct 3, 2002·Journal of Neurochemistry·Christopher M ButtAllan C Collins
May 6, 2005·American Journal of Physiology. Cell Physiology·Christianne E StrangKent T Keyser
Feb 27, 2018·Frontiers in Neural Circuits·Tomas Vega-ZunigaHarald Luksch
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Christopher M ButtAllan C Collins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.