A novel class of antitumour agents. I. Chemistry and animal experiments

Cancer Letters
D S SavageU Mohr

Abstract

Newly synthesized tertiary amino steroids, among them 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP), were tested in three animal species as to their antitumour activity against transplantable tumours. The acute toxicity of DAP was similar to that of cyclophosphamide and considerably lower than vinblastine. Rats with Walker ascites, treated intraperitoneally with DAP, survived up to one year without ascites; untreated animals died within 10 days of transplantation. Intragastric and intraperitoneal application of DAP caused side effects suggesting a local toxicity.

References

Sep 1, 1973·The Medical Letter on Drugs and Therapeutics
Nov 1, 1970·Journal of Pharmaceutical Sciences·K Y Zee-Cheng, C C Cheng
Sep 1, 1953·American Industrial Hygiene Association Quarterly·C S WEILH F SMYTH

Related Concepts

2,16-dipiperidinoandrostane-3,17-diol dipivalate, hydrochloride, (2beta,3alpha,5alpha,16beta,17beta)-isomer
Amines
Metazoa
Antineoplastic Agents
Cyclophosphamide, (S)-Isomer
Dye Exclusion Assays, Antitumor
Cricetus
Mesocricetus
Neoplasms, Experimental
Pancuronium Curamed

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