A novel class of antitumour agents. II. In vitro testing

Cancer Letters
A EmmingerD S Savage


Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose dependent within a certain range. With lower nontoxic doses, decreases in the mitotic and labelling indices were observed, and clotted mitotic figures occurred. The effects were essentially the same for all experimental cell types; chromosome alterations were not seen.


Jan 29, 1960·Biochimica Et Biophysica Acta·C P STANNERS, J E TILL
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD


Sep 3, 2011·Science·Gary D WuJames D Lewis
May 26, 2012·Food & Function·Paola VitaglioneNicoletta Pellegrini

Related Concepts

2,16-dipiperidinoandrostane-3,17-diol dipivalate, hydrochloride, (2beta,3alpha,5alpha,16beta,17beta)-isomer
Antineoplastic Agents
Carcinoma 256, Walker
Dye Exclusion Assays, Antitumor
HeLa Cells
Lymphocyte Activation
Lymphoid Cells
Pancuronium Curamed

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