A novel class of interstitial cells in the mouse and monkey female reproductive tracts

Biology of Reproduction
L E PeriSean M Ward

Abstract

Growing evidence suggests important roles for specialized platelet-derived growth factor receptor alpha-positive (PDGFRalpha(+)) cells in regulating the behaviors of visceral smooth muscle organs. Examination of the female reproductive tracts of mice and monkeys showed that PDGFRalpha(+) cells form extensive networks in ovary, oviduct, and uterus. PDGFRalpha(+) cells were located in discrete locations within these organs, and their distribution and density were similar in rodents and primates. PDGFRalpha(+) cells were distinct from smooth muscle cells and interstitial cells of Cajal (ICC). This was demonstrated with immunohistochemical techniques and by performing molecular expression studies on PDGFRalpha(+) cells from mice with enhanced green fluorescent protein driven off of the endogenous promoter for Pdgfralpha. Significant differences in gene expression were found in PDGFRalpha(+) cells from ovary, oviduct, and uterus. Differences in gene expression were also detected in cells from different tissue regions within the same organ (e.g., uterine myometrium vs. endometrium). PDGFRalpha(+) cells are unlikely to provide pacemaker activity because they lack significant expression of key pacemaker genes found in ICC (Kit and Ano1...Continue Reading

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Citations

Feb 18, 2017·International Journal of Molecular Sciences·Beatrice Mihaela RaduSanda Maria Cretoiu
Jun 15, 2017·American Journal of Obstetrics and Gynecology·Carmen GanRanjit Manchanda
Feb 1, 2018·The Journal of Physiology·Bernard T DrummKenton M Sanders
Feb 12, 2017·Advances in Physiology Education·Bernard T Drumm, Salah A Baker
May 18, 2020·The Journal of Physiology·Nathan GraingerKenton M Sanders
Dec 19, 2020·Acta Physiologica·Manasi MalikSarah K England

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Methods Mentioned

BETA
fluorescence-activated cell sorting
dissection
FACS
PCR

Software Mentioned

Photoshop
Corel Draw
Adobe Photoshop

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