A novel clinical applicable bed-side tool for assessing conditioning pain modulation: proof-of-concept.

Scandinavian Journal of Pain
Lars Arendt-NielsenPascal Madeleine

Abstract

Background and aims In recent years, focus on assessing descending pain modulation or conditioning pain modulation (CPM) has emerged in patients with chronic pain. This requires reliable and simple to use bed-side tools to be applied in the clinic. The aim of the present pilot study was to develop and provide proof-of-concept of a simple clinically applicable bed-side tool for assessing CPM. Methods A group of 26 healthy volunteers participated in the experiment. Pressure pain thresholds (PPT) were assessed as test stimuli from the lower leg before, during and 5 min after delivering the conditioning tonic painful pressure stimulation. The tonic stimulus was delivered for 2 min by a custom-made spring-loaded finger pressure device applying a fixed pressure (2.2 kg) to the index finger nail. The pain intensity provoked by the tonic stimulus was continuously recorded on a 0-10 cm Visual Analog Scale (VAS). Results The median tonic pain stimulus intensity was 6.7 cm (interquartile range: 4.6-8.4 cm) on the 10 cm VAS. The mean PPT increased significantly (P = 0.034) by 55 ± 126 kPa from 518 ± 173 kPa before to 573 ± 228 kPa during conditioning stimulation. When analyzing the individual CPM responses (increases in PPT), a distributio...Continue Reading

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Citations

Apr 28, 2021·Current Opinion in Supportive and Palliative Care·Maren ReimerRalf Baron
May 28, 2021·Scandinavian Journal of Pain·Søren O'NeillCasper Glissmann Nim
May 20, 2021·Current Opinion in Supportive and Palliative Care·Maren ReimerRalf Baron

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