A novel clinically-oriented classification of fine-needle aspiration cytology for salivary gland tumors: a 20-year retrospective analysis of 1175 patients.

International Journal of Clinical Oncology
Masataka TaniuchiYoshinobu Hirose

Abstract

When determining treatment strategy for a salivary gland tumor, assessing histology and malignancy grade before surgery is essential. Several new diagnostic classification systems for salivary gland cytology have recently been proposed. However, none incorporate histology and grade of malignancy. We developed a new cytology classification system that incorporates histology and grade of malignancy of salivary gland tumors (OMC classification), consisting of 11 categories. Our OMC classification was applied to 1175 patients who had preoperative cytology and confirmed final pathological diagnosis available from the past 20 years at our hospital (benign tumor: 981 patients, malignant tumor: 194 patients). Based on the cytology, 729 patients (62.0%) had benign histology (Category 4-1), and 87 patients (7.4%) were diagnosed with grade of malignancy (Category 6-3 + 6-4). Based on the final pathological diagnosis, the accuracy rate of Category 4-1 and Category 6-3 + 6-4 of our classification system was 93.4% and 88.5%, respectively. Based on the correct diagnosis rate, the inclusion of histology and grade of malignancy in the salivary gland cytology classification was considered feasible. Thus, the OMC classification system is consider...Continue Reading

References

Sep 18, 2010·Head & Neck·Laura L VederMichael A den Bakker
Oct 8, 2014·The Laryngoscope·Robert Lee WittPeter Zbären
May 15, 2015·American Journal of Clinical Pathology·Christopher C GriffithRaja R Seethala
Dec 1, 2015·Archives of Pathology & Laboratory Medicine·He WangNirag Jhala
Apr 21, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Aaron J FeinsteinMaie St John
Jul 15, 2017·Cancer Cytopathology·Esther Diana RossiDaniel F I Kurtycz
Aug 7, 2017·The Laryngoscope·Danielle F EytanChristine G Gourin
Mar 23, 2018·International Journal of Clinical Oncology·Akira NishikadoYoshinobu Hirose
Jan 3, 2019·Advances in Anatomic Pathology·Marc PusztaszeriWilliam C Faquin

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