A novel combination regimen for the treatment of refractory bacteremia due to multidrug-resistant Pseudomonas aeruginosa in a liver transplant recipient

Transplant Infectious Disease : an Official Journal of the Transplantation Society
H-Y SunN Singh

Abstract

Both bacteremia and biliary cast syndrome are serious post-transplant complications in liver transplant recipients. In the setting of increasing drug resistance in the current era, management of infections caused by multidrug-resistant (MDR) bacteria has proven challenging. We present a case of a liver transplant recipient who developed biliary cast syndrome and intractable MDR Pseudomonas bacteremia that failed to resolve with conventional antimicrobial therapy and which was finally controlled by a novel combination regimen of colistimethate, doripenem, and tobramycin. Future studies validating the clinical efficacy of this combination strategy are warranted.

References

Jan 1, 1978·Chemotherapy·E T AndersonW L Hewitt
Mar 1, 1980·The American Journal of Medicine·B E KregerW R McCabe
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J WadeR Williams
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S LevinS F Costa
Jan 11, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N SinghI R Marino
Apr 20, 2001·Intensive Care Medicine·P Y BochudUNKNOWN International Sepsis Forum
Mar 26, 2003·European Journal of Gastroenterology & Hepatology·Sally D Parry, Paolo Muiesan
Nov 13, 2003·Transplantation Proceedings·J S BarkunJ I Tchervenkov
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nina SinghTimothy Gayowski
Aug 4, 2004·The Lancet Infectious Diseases·Nasia SafdarDennis G Maki
Jan 25, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·See Ching ChanSheung Tat Fan
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ioannis A BliziotisMatthew E Falagas
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert GaynesUNKNOWN National Nosocomial Infections Surveillance System
Aug 9, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert A Bonomo, Dora Szabo
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A MorenoJ Carratalá
Oct 31, 2007·Antimicrobial Agents and Chemotherapy·Glenn A PankuchPeter C Appelbaum
Oct 10, 2008·Academic Medicine : Journal of the Association of American Medical Colleges·Rachel YudkowskyMihaela Popescu
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Niraj V GorStanley Martin Cohen
Jan 17, 2009·The Journal of Antimicrobial Chemotherapy·Nobumasa AokiKeizo Yamaguchi
Mar 24, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L E JohnsonA Y Peleg
Apr 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M N Al-HasanL M Baddour
Jul 30, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S H ShiS S Zheng
Aug 22, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lance R Peterson

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Citations

Oct 9, 2013·Current Infectious Disease Reports·Gopi PatelShirish Huprikar
May 31, 2014·World Journal of Gastroenterology : WJG·Guilherme Santoro-Lopes, Erika Ferraz de Gouvêa
Dec 10, 2015·Infectious Diseases and Therapy·Phillip J BergenBrian T Tsuji
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D van DuinUNKNOWN AST Infectious Diseases Community of Practice
Aug 16, 2011·Transplantation Proceedings·R C Moellering
Nov 13, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Qq WanH Yuan
Nov 3, 2005·Clinics in Chest Medicine·Leanne B Gasink, Emily A Blumberg
Apr 6, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Aijing LuoQifa Ye
Feb 26, 2021·Pharmacological Reviews·Sue C NangJian Li

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