A novel concurrent TMS-fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Human Brain Mapping
Jord J T VinkSebastiaan F W Neggers

Abstract

Major depressive disorder (MDD) is a severe mental disorder associated with high morbidity and mortality rates, which remains difficult to treat, as both resistance and recurrence rates are high. Repetitive transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) provides a safe and effective treatment for selected patients with treatment-resistant MDD. Little is known about the mechanisms of action of TMS provided to the left DLPFC in MDD and we can currently not predict who will respond to this type of treatment, precluding effective patient selection. In order to shed some light on the mechanism of action, we applied single pulse TMS to the left DLPFC in 10 healthy participants using a unique TMS-fMRI set-up, in which we could record the direct effects of TMS. Stimulation of the DLPFC triggered activity in a number of connected brain regions, including the subgenual anterior cingulate cortex (sgACC) in four out of nine participants. The sgACC is of particular interest, because normalization of activity in this region has been associated with relief of depressive symptoms in MDD patients. This is the first direct evidence that TMS pulses delivered to the DLPFC can propagate to the sgACC. The ...Continue Reading

References

Aug 12, 1999·The Journal of Comparative Neurology·K AmuntsK Zilles
Sep 3, 2002·Journal of Neuroscience Methods·John E Desmond, Gary H Glover
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jul 9, 2005·NeuroImage·Sven BestmannJens Frahm
Feb 9, 2006·Brain Research Bulletin·S K EsserG Tononi
Jun 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Sep 8, 2006·The Journal of ECT·Dennis J L G Schutter, Jack van Honk
Jan 24, 2007·NeuroImage·Bertrand ThirionJean-Baptiste Poline
Mar 27, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Seiko IshikawaJohn C Rothwell
Apr 2, 2008·The Journal of ECT·Anna IngramIsaac Schweitzer
Oct 1, 2008·Journal of Cognitive Neuroscience·Alexander T SackRainer Goebel
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul B FitzgeraldZafiris J Daskalakis
Oct 15, 2009·Acta Psychiatrica Scandinavica·Bradley Ng
Oct 17, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiUNKNOWN Safety of TMS Consensus Group
Jul 17, 2012·NeuroImage·Daniel A HandwerkerPeter A Bandettini
Nov 14, 2012·Cerebral Cortex·Elena A AllenVince D Calhoun
Mar 13, 2013·The Journal of Physiology·Asif RahmanMarom Bikson
Jan 11, 2014·World Journal of Urology·Viktor Grünwald, Alain Ravaud
Jan 23, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Chris BaekenRudi De Raedt
Oct 2, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Antoin D de WeijerSebastiaan F W Neggers
Nov 2, 2016·Journal of Neurosurgery·Darin D DoughertyThilo Deckersbach

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Citations

Sep 26, 2019·Psychiatry Investigation·Chien-Han Lai
Apr 8, 2020·The American Journal of Psychiatry·Eleanor J ColeNolan R Williams
Feb 25, 2020·Brain Topography·Jord J T VinkMouhsin M Shafi
Mar 19, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Lucas BorrioneAndre R Brunoni
Jul 10, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Samuel ZibmanAbraham Zangen
Feb 10, 2021·Experimental Brain Research·Desmond J OathesKristin A Linn
Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chien-Han Lai
Dec 17, 2020·Frontiers in Neurology·Abrahão Fontes BaptistaYossi Zana
Mar 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tonisha Kearney-Ramos, Margaret Haney
May 1, 2021·Brain Sciences·Lysianne BeynelLawrence G Appelbaum
May 4, 2021·NeuroImage·Til Ole BergmannHartwig Roman Siebner
Aug 24, 2020·NeuroImage·Maximilian A FriehsGesa Hartwigsen
Aug 5, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stefano PallantiJoseph Zohar
Aug 24, 2021·Frontiers in Human Neuroscience·Sachin Pradeep Baliga, Urvakhsh Meherwan Mehta

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Methods Mentioned

BETA
pharmacotherapy
SMA

Software Mentioned

MATLAB
custom
SPM
SPM12

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