A Novel Coronavirus from Patients with Pneumonia in China, 2019

The New England Journal of Medicine
Na ZhuChina Novel Coronavirus Investigating and Research Team

Abstract

In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.).

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Citations

Feb 23, 2020·Radiology·Zi Yue ZuLong Jiang Zhang
Jan 29, 2020·The New England Journal of Medicine·Lan T PhanQuang D Pham
Feb 1, 2020·Radiology·Junqiang LeiXiaolong Qi
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
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Mar 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shutoku MatsuyamaMakoto Takeda
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Mar 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiaotong WangXinghua Shen
Mar 4, 2020·JAMA : the Journal of the American Medical Association·Barnaby Edward YoungUNKNOWN Singapore 2019 Novel Coronavirus Outbreak Research Team
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Apr 11, 2020·Basic Research in Cardiology·Paola RizzoRoberto Ferrari

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Datasets Mentioned

BETA
MG772933.1

Methods Mentioned

BETA
bronchoalveolar-lavage
reverse transcription PCR
transmission electron microscopy
Illumina sequencing
PCR
biopsy
light
light microcopy

Software Mentioned

RespiFinderSmart22kit
RAxML
Muscle
CLC Genomics

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