A Novel Coronavirus from Patients with Pneumonia in China, 2019

The New England Journal of Medicine
Na ZhuChina Novel Coronavirus Investigating and Research Team


In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.).

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Datasets Mentioned


Methods Mentioned

reverse transcription PCR
transmission electron microscopy
Illumina sequencing
light microcopy

Software Mentioned

CLC Genomics

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