A novel cubic phase of medium chain lipid origin for the delivery of poorly water soluble drugs

Journal of Controlled Release : Official Journal of the Controlled Release Society
Greg A KossenaChristopher J H Porter

Abstract

The existence of a novel cubic liquid crystalline phase is described within the pseudo-ternary system comprising lauric acid, monolaurin, and simulated endogenous intestinal fluid (SEIF). This phase behaviour has been characterized using cross-polarizing light microscopy (CPLM), and the structure of the cubic phase identified by small angle X-ray scattering (SAXS). The presence of the cubic phase was found to be temperature sensitive within the 20-37 degrees C range making it putative material for in situ gelation purposes. The cubic phase was shown to have a high capacity to solubilise a model poorly water-soluble drug, cinnarizine, and initial in vitro release data highlight the potential of this phase to provide sustained release. Absorption of cinnarizine from the cubic phase was studied in an unconscious rat model via duodenal administration and blood sampling via the carotid artery. The rate of absorption was significantly reduced when compared to a simple suspension formulation, a likely combination of retarded erosion of the cubic phase together with hindered drug release from the cubic matrix. The results of this study suggest that this cubic phase may potentially be of benefit in the delivery of poorly water-soluble c...Continue Reading

References

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Citations

Jul 25, 2012·Therapeutic Delivery·Thanigaivel Shanmugam, Rinti Banerjee
Jan 19, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·René HolmPeter Westh
Dec 25, 2004·Journal of Pharmaceutical Sciences·Greg A KossenaChristopher J H Porter
Jan 19, 2016·Drug Discovery Today·Zahra Karami, Mehrdad Hamidi
Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tri-Hung NguyenBen J Boyd
Jul 28, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Stephanie PhanBen J Boyd
Jun 5, 2013·Colloids and Surfaces. B, Biointerfaces·Lorena TavanoRita Muzzalupo
Jul 23, 2014·Colloids and Surfaces. B, Biointerfaces·Marganit Cohen-AvrahamiNissim Garti
Dec 9, 2014·Journal of Colloid and Interface Science·Stephanie PhanBen J Boyd
Nov 17, 2010·Physical Chemistry Chemical Physics : PCCP·Borislav AngelovJan Skov Pedersen
Dec 6, 2014·International Journal of Pharmaceutics·Spomenka Milak, Andreas Zimmer
Jun 21, 2016·International Journal of Pharmaceutics·Shyamal C Das, Peter J Stewart
Aug 15, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Da DongBen J Boyd
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd
Feb 19, 2021·Journal of Pharmaceutical Sciences·Amira Mohamed MohsenAsmaa Badawy Darwish
Mar 7, 2021·Drug Delivery and Translational Research·Chelsea R ThornClive A Prestidge
Dec 20, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zhen LiZhongni Wang
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Tomohiro ImuraDai Kitamoto

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