A novel cyclo-oxygenase-2 inhibitor modulates catabolic and antiinflammatory mediators in osteoarthritis

Biochemical Pharmacology
P FernándezM J Alcaraz

Abstract

ITB (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2',3':1,5]-1,2,4-triazolo[4,3-a]-1,3,5-benzotriazepine) is a novel inhibitor of cyclo-oxygenase-2 (COX-2) with antiinflammatory activity in animal models. In the present study, we investigated the effect of this compound on the production of catabolic or antiinflammatory mediators in osteoarthritis (OA) cartilage. In OA cartilage explants, ITB inhibited the production of prostaglandin E(2) (PGE(2)), tumour necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-13 (MMP-13) in a concentration-dependent manner, whereas nitrite was partially reduced. On the contrary, ITB increased the production of interleukin (IL)-10 and the expression of heme oxygenase-1 (HO-1). ITB inhibited the production of catabolic mediators at concentrations able to increase IL-10 and HO-1 in OA cartilage, suggesting that this compound may be useful in the prevention of cartilage degradation.

References

May 8, 1998·The American Journal of Medicine·J R Vane, R M Botting
Oct 17, 1998·Cancer Investigation·T L YakshA B Malmberg
Dec 21, 2000·Current Rheumatology Reports·M B Goldring
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Jan 16, 2003·Seminars in Arthritis and Rheumatism·Marc C Hochberg
Apr 1, 2003·Advances in Experimental Medicine and Biology·Alane KokiJaime L Masferrer
Oct 8, 2003·Current Pharmaceutical Design·M J AlcarazM I Guillén
Nov 6, 2003·Biochemical Pharmacology·Patricia FernándezMaria José Alcaraz

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Citations

Aug 17, 2006·Antioxidants & Redox Signaling·Benedetta Bussolati, Justin C Mason
Jan 18, 2008·The Journal of Pathology·Mi GuillénMj Alcaraz
Sep 19, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A GloriaN O S Câmara
Sep 17, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Taro MawatariRobert L Smith

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