A novel DCL2-dependent miRNA pathway in tomato affects susceptibility to RNA viruses

Genes & Development
Zhengming WangDavid C Baulcombe

Abstract

Tomato Dicer-like2 (slDCL2) is a key component of resistance pathways against potato virus X (PVX) and tobacco mosaic virus (TMV). It is also required for production of endogenous small RNAs, including miR6026 and other noncanonical microRNAs (miRNAs). The slDCL2 mRNAs are targets of these slDCL2-dependent RNAs in a feedback loop that was disrupted by target mimic RNAs of miR6026. In lines expressing these RNAs, there was correspondingly enhanced resistance against PVX and TMV. These findings illustrate a novel miRNA pathway in plants and a crop protection strategy in which miRNA target mimicry elevates expression of defense-related mRNAs.

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Citations

Nov 21, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Shuai SunXia Cui
Mar 19, 2020·Applied Microbiology and Biotechnology·Isabella PentimoneAurelio Ciancio
Jun 27, 2019·Horticulture Research·Tian WangHongliang Zhu
Aug 15, 2020·Nature Communications·Marisol DomínguezLeandro Quadrana
Jan 10, 2020·Briefings in Functional Genomics·Shakeel AhmadShaoqing Tang
Jan 16, 2021·International Journal of Molecular Sciences·Hymavathi SalavaFatemeh Maghuly
Mar 24, 2021·Briefings in Bioinformatics·Yongxin ZhaoXiaozeng Yang
Sep 28, 2020·Journal of Biotechnology·Mujtaba Aamir BhatArif Tasleem Jan
Sep 28, 2021·Virology Journal·Paola LeonettiVitantonio Pantaleo

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