A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms

Digestive Diseases and Sciences
Brooks D CashSyed M Shah

Abstract

Peppermint oil (PO) has shown promise as an IBS therapy, but previous trials have demonstrated variable efficacy and tolerability results. To evaluate the efficacy and tolerability of a novel formulation of PO designed for sustained release in the small intestine in patients with IBS-M and IBS-D. This is a 4-week, randomized, double-blind, placebo-controlled clinical trial of PO or identical placebo 3 times daily in patients fulfilling Rome III criteria for IBS-M or IBS-D. The primary endpoint was the change from baseline in the Total IBS Symptom Score (TISS) after 4 weeks of treatment. Seventy-two patients (mean age 40.7 years, 75 % female, 77.8 % white) were randomized to PO (n = 35) or placebo (n = 37). At 4 weeks, PO was associated with a 40 % reduction in the TISS from baseline (mean change -1.16, SD ± 0.807), superior to the 24.3 % decrease (mean change -0.70, SD ± 0.737) observed with placebo (P = 0.0246). The decrease in the TISS of 19.6 % (mean change -0.55, SD ± 0.613) in the PO group at 24 h was also significantly larger than placebo (-10.3 %, mean change -0.27, SD ± 0.342) (P = 0.0092). At trial completion, patients in the PO group experienced greater improvement in multiple individual gastrointestinal symptoms as w...Continue Reading

References

Oct 6, 1979·British Medical Journal·W D ReesJ Rhodes
Sep 2, 1978·British Medical Journal·A P ManningA F Morris
Oct 1, 1984·British Journal of Clinical Pharmacology·K W SomervilleG D Bell
May 11, 1999·The American Journal of Gastroenterology·T LemboE A Mayer
Aug 25, 1999·Clinical Pharmacology and Therapeutics·A GelalN L Benowitz
Mar 19, 2002·Neuroscience Letters·Nicoletta GaleottiCarla Ghelardini
Aug 23, 2002·The American Journal of Gastroenterology·Yuri A SaitoG Richard Locke
Mar 15, 2005·Gastroenterology·Beatrice SalvioliJuan-R Malagelada
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Jun 15, 2006·The American Journal of Gastroenterology·Simon P DunlopRobin C Spiller
Apr 11, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G CappelloL Marzio
Jun 10, 2009·Digestive Diseases and Sciences·Shahin MeratReza Malekzadeh
Feb 19, 2011·Journal of Gastroenterology·Alexander C Ford, Nicholas J Talley
Jul 13, 2011·The American Journal of Gastroenterology·Douglas A DrossmanP Whorwell
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
Oct 9, 2013·Journal of Clinical Gastroenterology·Reena KhannaBarrett G Levesque
Apr 9, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J WalstabB Niesler
Aug 6, 2014·The American Journal of Gastroenterology·Alexander C FordEamonn M M Quigley
Sep 10, 2014·Alimentary Pharmacology & Therapeutics·C CanavanT Card
Apr 14, 2015·Scandinavian Journal of Gastroenterology·Evangelos Giamarellos-BourboulisMark Pimentel

❮ Previous
Next ❯

Citations

Dec 23, 2015·Digestive Diseases and Sciences·Lucinda A Harris
Apr 20, 2017·Journal of Medicinal Food·Matteo MicucciRoberta Budriesi
Jun 29, 2017·The New England Journal of Medicine·Alexander C FordNicholas J Talley
Feb 25, 2017·Gut·Michael Camilleri, Guy Boeckxstaens
Oct 28, 2017·Journal of Clinical Medicine·Michael Camilleri, Alexander C Ford
Sep 9, 2017·Alimentary Pharmacology & Therapeutics·A B BeckersD Keszthelyi
Nov 15, 2017·Current Gastroenterology Reports·Brent W Acker, Brooks D Cash
Feb 1, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S BotschuijverR M van den Wijngaard
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Codruta HeghesLorena Filip
May 10, 2016·Nature Reviews. Disease Primers·Paul EnckRobin C Spiller
Apr 27, 2019·Current Gastroenterology Reports·Akhil MunjalBrooks Cash
Apr 8, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dafne BalemansMira M Wouters
Aug 19, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Adam J KuchniaNorman Greenberg
Jan 19, 2019·BMC Complementary and Alternative Medicine·N AlammarG E Mullin
Nov 20, 2019·Holistic Nursing Practice·Patricia M Childers, Mollie E Aleshire
Sep 6, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Eirini DimidiKevin Whelan
Feb 23, 2020·The American Journal of Gastroenterology·Jill K DeutschDavid J Hass
Jun 23, 2018·Nature Reviews. Gastroenterology & Hepatology·Magnus Simrén, Jan Tack
Nov 7, 2018·Current Gastroenterology Reports·Hans Törnblom, Douglas A Drossman
Jul 12, 2019·Journal of the Canadian Association of Gastroenterology·Paul MoayyediStephen Vanner
Apr 19, 2018·The Nurse Practitioner·Rosanne PruittAdam Carroll
Jun 29, 2018·The American Journal of Gastroenterology·Alexander C FordUNKNOWN ACG Task Force on Management of Irritable Bowel Syndrome
Jun 9, 2018·World Journal of Gastroenterology : WJG·Niranga Manjuri Devanarayana, Shaman Rajindrajith
Apr 22, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Bani AhluwaliaLena Öhman
Mar 14, 2017·Therapeutic Advances in Gastroenterology·Santosh SanagapalliCrispin John Corte
Nov 3, 2017·Current Opinion in Gastroenterology·Orla Craig
May 7, 2020·Frontiers in Neuroscience·Viola BrugnatelliGastone Zanette
Jul 6, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Nazanin Momeni RoudsariAmir Hossein Abdolghaffari
Jun 11, 2020·Digestive Diseases and Sciences·James Y HanWilliam Karnes
May 10, 2020·Expert Opinion on Drug Metabolism & Toxicology·Taraneh MousaviMohammad Abdollahi
Oct 9, 2020·Clinical and Translational Gastroenterology·Qiang YouYouping Liu
Dec 15, 2020·The American Journal of Gastroenterology·Brian E LacyBaha Moshiree
Feb 11, 2021·Current Medical Research and Opinion·Jennifer JonesBrian Lacy
Apr 5, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian E LacyMaria Vazquez-Roque
Jan 23, 2021·The American Journal of Gastroenterology·Sarvee MoosaviAli Rezaie
Mar 9, 2021·Frontiers in Pharmacology·Esther ColomierChloé Melchior
Dec 14, 2018·Mayo Clinic Proceedings·Michael Camilleri
Jul 29, 2020·Gastroenterology Clinics of North America·Lauren Stemboroski, Ron Schey
Jun 8, 2021·Frontiers in Endocrinology·Sik Yu So, Tor C Savidge
May 28, 2020·Frontline Gastroenterology·Christopher J Black, Alexander Charles Ford

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

SAS
IBSREST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Guillaume Pineton de ChambrunPierre Desreumaux
The American Journal of Gastroenterology
T R Koch
© 2021 Meta ULC. All rights reserved