A novel dose constraint to reduce xerostomia in head-and-neck cancer patients treated with intensity-modulated radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Lidia StrigariLaura Marucci

Abstract

To investigate the predictors of incidence and duration of xerostomia (XT) based on parotid glands (PG), submandibular glands (SMG), and both glands taken as a whole organ (TG) in head-and-neck cancer patients treated with intensity-modulated radiotherapy. A prospective study was initiated in May 2003. Sixty-three head-and-neck patients (44 with nasopharynx cancer) were included in the analysis. Using the dose-volume histogram the PG, SMG, and TG mean doses were calculated. Unstimulated and stimulated salivary flow were measured and XT-related questionnaires were compiled before and at 3, 6, 12, 18, and 24 months after radiotherapy. Salivary gland toxicity was evaluated using the Radiation Therapy Oncology Group scale, and Grade >or=3 toxicity was used as the endpoint. The XT incidence was investigated according to descriptive statistics and univariate and multivariate analysis. The Bonferroni method was used for multiple comparison adjustment. After a reduced flow at 3 months after radiotherapy, recovery of salivary flow was observed over time. Primary site and salivary gland mean doses and volumes were identified in univariate analysis as prognostic factors. Multivariate analysis confirmed that TG mean dose (p = 0.00066) and ...Continue Reading

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Citations

Jul 5, 2015·Critical Reviews in Oncology/hematology·Antonio SchindlerBarbara Murphy
Jun 27, 2014·BioMed Research International·Jia-Ming WuTsair-Fwu Lee
Mar 27, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Florian BuettnerChristopher M Nutting
Feb 9, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·O Kyu NohJun Chul Lim
Jan 24, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Arjen van der SchaafCornelis Schilstra
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Feb 7, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wen-Jun FanLin Ma
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Nov 22, 2019·Frontiers in Oncology·Vincent W C Wu, Kit Yee Leung
Feb 16, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wen-Jun FanJian Guan

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