A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells

Journal of Controlled Release : Official Journal of the Controlled Release Society
Yoshiro TaharaMasahiro Goto

Abstract

A novel intracellular delivery method both for genes and proteins is one of the most coveted systems in the drug delivery field. In the present study, we developed a double-coating carrier loaded with gene and protein produced by solid-in-oil and solid-in-water nanodispersion technology. The double-coating carriers did not require electrostatic interactions during the preparation so were able to encapsulate plasmid DNA, ovalbumin (pI 4.5), horseradish peroxidase (pI 7.2), and cytochrome-c (pI 10.5) in a consistent manner. The carriers had practical encapsulation efficiencies and release profiles for genes and proteins. Furthermore, effective gene expression and cellular uptakes of both anionic and cationic proteins were achieved by modification of carriers with functional molecules. These findings indicate that the double-coating carrier has high potential for cellular delivery of various drugs and is a novel, superior method for both gene and protein delivery into cells.

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Citations

Jan 9, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Md Nazir HossenHideyoshi Harashima
May 30, 2013·International Journal of Nanomedicine·Riki ToitaMakoto Hashizume
Jun 12, 2014·Electrophoresis·Chih-Hui YangKeng-Shiang Huang
Mar 31, 2015·Journal of Materials Science. Materials in Medicine·Junjie YuanYouzhuan Xie
May 25, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Orit AmsalemEylon Yavin

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